Document Detail


Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning.
MedLine Citation:
PMID:  8485479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No prospective data have documented the physical and psychosocial functioning of patients before and after BMT. In this study 67 allogeneic transplant patients completed standardized self-report measures pre-transplant. Survivors were re-assessed at 90 days (n = 34) and 1 year (n = 31) post-transplant. Telephone interviews established 4-year work history and performance status. Physical function was most impaired at 90 days post-transplant, with a return to pre-transplant levels of functioning by 1 year in most areas. By 2 years post-transplant, 68% of patients had returned to full-time work. Only 9% of 4-year survivors failed to return to full-time occupations. Mean levels of anxiety and depression did not change over the first year. Pre-transplant, 27% of patients reported depression and 41% reported elevated anxiety. Greater emotional distress at 1 year was predicted by pre-transplant family conflict, non-married status and development of less severe chronic GVHD. Impaired physical recovery at 1 year was predicted by more severe chronic GVHD, pre-transplant physical impairment and family conflict. The large majority of long-term survivors returned to full-time employment with normal physical and psychosocial functioning, although recovery took longer than 1 year for approximately 40%. Family relationships were important determinants of physical and emotional recovery.
Authors:
K L Syrjala; M K Chapko; P P Vitaliano; C Cummings; K M Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  11     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-06-04     Completed Date:  1993-06-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
Affiliation:
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety / etiology
Bone Marrow Transplantation* / psychology
Chronic Disease
Conflict (Psychology)
Convalescence* / psychology
Depression / etiology
Employment
Female
Graft vs Host Disease / psychology
Humans
Leukemia / psychology,  surgery*
Lymphoma / psychology,  surgery
Male
Marriage
Middle Aged
Predictive Value of Tests
Prospective Studies
Psychological Tests
Quality of Life*
Remission Induction
Severity of Illness Index
Treatment Outcome
Grant Support
ID/Acronym/Agency:
CA18029/CA/NCI NIH HHS; CA18221/CA/NCI NIH HHS; CA38552/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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