Document Detail

Recovery of [13C]-bicarbonate as respiratory 13CO2 in parenterally fed infants.
MedLine Citation:
PMID:  2162296     Owner:  NLM     Status:  MEDLINE    
Ten infants on continuous total parenteral nutrition (TPN) were infused with NaH13CO3 for 6 h in order to assess the amount of 13C recovered as breath 13CO2. Protein intake was 2.8 +/- 0.3 g/kg/d and non-protein energy intake 107 +/- 4 kcal/kg/d (447 +/- 18 kJ/kg/d), provided either as glucose alone or as an isoenergetic glucose-lipid mixture. In the five infants receiving glucose as the sole non-protein energy source, total CO2 production (559 +/- 50 mumol/kg/min), natural 13C abundance of breath CO2 (-11.8 +/- 0.6 delta % versus PDB) and basal 13CO2 production (6.1 +/- 0.6 mumol/kg/min) were higher than in the five infants infused the glucose-lipid mixture (465 +/- 30 mumol/kg/min, P less than 0.02; -16.1 +/- 0.5 delta %, P less than 0.01 and 5.0 +/- 0.3 mumol/kg min, P less than 0.02, respectively). There was a good agreement, in the glucose-infused infants, between the net glucose oxidation rate measured by indirect calorimetry (25.6 +/- 2 g/kg/d) and the glucose oxidation rate estimated from the 13C natural abundances of breath CO2 and infused substrates (23.5 +/- 3 g/kg/d). Steady state 13C enrichment of breath CO2 was reached in all infants after 120 min infusion and ranged from 11.0 to 21.5 delta % over baseline. Steady state 13C enrichment was negatively related to total CO2 production (r = -0.72; P less than 0.02). In contrast, steady state 13CO2 production in excess of baseline was only correlated to bicarbonate infusion rate (r = 0.95; P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
J L Bresson; A Mariotti; P Narcy; C Ricour; C Sachs; J Rey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  44     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-07-20     Completed Date:  1990-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Département de Pédiatrie, CNRS UA 1286, Hôpital des Enfants Malades, Paris, France.
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MeSH Terms
Bicarbonates / administration & dosage,  metabolism*
Breath Tests
Calorimetry, Indirect
Carbon / analysis,  metabolism
Carbon Dioxide / analysis,  metabolism*
Carbon Isotopes
Food, Formulated*
Glucose / administration & dosage,  metabolism
Infusions, Intravenous
Parenteral Nutrition, Total*
Pulmonary Gas Exchange
Sodium / administration & dosage,  metabolism*
Sodium Bicarbonate
Reg. No./Substance:
0/Bicarbonates; 0/Carbon Isotopes; 124-38-9/Carbon Dioxide; 144-55-8/Sodium Bicarbonate; 50-99-7/Glucose; 7440-23-5/Sodium; 7440-44-0/Carbon

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