| Recovery of [13C]-bicarbonate as respiratory 13CO2 in parenterally fed infants. | |
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MedLine Citation:
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PMID: 2162296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten infants on continuous total parenteral nutrition (TPN) were infused with NaH13CO3 for 6 h in order to assess the amount of 13C recovered as breath 13CO2. Protein intake was 2.8 +/- 0.3 g/kg/d and non-protein energy intake 107 +/- 4 kcal/kg/d (447 +/- 18 kJ/kg/d), provided either as glucose alone or as an isoenergetic glucose-lipid mixture. In the five infants receiving glucose as the sole non-protein energy source, total CO2 production (559 +/- 50 mumol/kg/min), natural 13C abundance of breath CO2 (-11.8 +/- 0.6 delta % versus PDB) and basal 13CO2 production (6.1 +/- 0.6 mumol/kg/min) were higher than in the five infants infused the glucose-lipid mixture (465 +/- 30 mumol/kg/min, P less than 0.02; -16.1 +/- 0.5 delta %, P less than 0.01 and 5.0 +/- 0.3 mumol/kg min, P less than 0.02, respectively). There was a good agreement, in the glucose-infused infants, between the net glucose oxidation rate measured by indirect calorimetry (25.6 +/- 2 g/kg/d) and the glucose oxidation rate estimated from the 13C natural abundances of breath CO2 and infused substrates (23.5 +/- 3 g/kg/d). Steady state 13C enrichment of breath CO2 was reached in all infants after 120 min infusion and ranged from 11.0 to 21.5 delta % over baseline. Steady state 13C enrichment was negatively related to total CO2 production (r = -0.72; P less than 0.02). In contrast, steady state 13CO2 production in excess of baseline was only correlated to bicarbonate infusion rate (r = 0.95; P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J L Bresson; A Mariotti; P Narcy; C Ricour; C Sachs; J Rey |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 44 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-07-20 Completed Date: 1990-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Affiliation:
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Département de Pédiatrie, CNRS UA 1286, Hôpital des Enfants Malades, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bicarbonates
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administration & dosage,
metabolism* Breath Tests Calorimetry, Indirect Carbon / analysis, metabolism Carbon Dioxide / analysis, metabolism* Carbon Isotopes Food, Formulated* Glucose / administration & dosage, metabolism Humans Infant Infusions, Intravenous Oxidation-Reduction Parenteral Nutrition, Total* Pulmonary Gas Exchange Sodium / administration & dosage, metabolism* Sodium Bicarbonate |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Carbon Isotopes; 124-38-9/Carbon Dioxide; 144-55-8/Sodium Bicarbonate; 50-99-7/Glucose; 7440-23-5/Sodium; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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