| Recovered neuronal viability revealed by Iodine-123-iomazenil SPECT following traumatic brain injury. | |
| | |
MedLine Citation:
|
PMID: 20683454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We evaluated cortical damages following traumatic brain injury (TBI) in the acute phase with [(123)I] iomazenil (IMZ) single photon emission computed tomography (SPECT). In all, 12 patients with cerebral contusion following TBI were recruited. All patients underwent IMZ SPECT within 1 week after TBI. To investigate the changes in distribution of IMZ in the cortex in the chronic phase, after conventional treatment, patients underwent IMZ SPECT again. A decrease in the accumulation of radioligand for the central benzodiazepine receptor in the cortex corresponding to the contusion revealed with computed tomography (CT) scans and magnetic resonance imaging (MRI) were shown on IMZ SPECT in the acute phase in all patients. In 9 of 12 patients (75%), images of IMZ SPECT obtained in the chronic phase of TBI showed that areas with a decreased distribution of IMZ were remarkably reduced in comparison with those obtained in the acute phase. Both CT scans and MRI showed a normal appearance of the cortex morphologically, where the binding potential of IMZ recovered in the chronic phase. Reduced binding potential of radioligand for the central benzodiazepine receptor is considered to be an irreversible reaction; however, in this study, IMZ accumulation in the cortex following TBI was recovered in the chronic phase in several patients. [(123)I] iomazenil SPECT may have a potential to disclose a reversible vulnerability of neurons following TBI. |
| | |
Authors:
|
Hiroyasu Koizumi; Hirosuke Fujisawa; Tetsu Kurokawa; Eiichi Suehiro; Hideyuki Iwanaga; Jyoji Nakagawara; Michiyasu Suzuki |
Related Documents
:
|
2266384 - A prospective comparison of rubidium-82 pet and thallium-201 spect myocardial perfusion... 12050314 - Computer-aided intrapatient comparison of brain spect images: the gray-level normalizat... 3117984 - Spect imaging of para-axial neurofibromatosis with technetium-99m dtpa. 12416584 - Attenuation correction of myocardial spect images with x-ray ct: effects of registratio... 17650554 - Technical requirements, biophysical considerations and protocol optimization with magne... 8796654 - Visual scanning patterns of radiologists searching mammograms. |
Publication Detail:
|
Type: Journal Article Date: 2010-08-04 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2010-10-27 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 1673-81 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan. hiroyasu@yamaguchi-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Brain / pathology, radionuclide imaging Brain Injuries / pathology*, radionuclide imaging* Cell Survival Female Flumazenil / analogs & derivatives*, diagnostic use Humans Iodine Radioisotopes / diagnostic use Male Middle Aged Neurons / pathology, radionuclide imaging* Receptors, GABA-A / analysis, metabolism Tomography, Emission-Computed, Single-Photon* / methods |
| Chemical | |
Reg. No./Substance:
|
0/Iodine Radioisotopes; 0/Receptors, GABA-A; 127396-36-5/iomazenil; 78755-81-4/Flumazenil |
| Comments/Corrections | |
Comment In:
|
J Cereb Blood Flow Metab. 2010 Oct;30(10):1671-2
[PMID:
20700134
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barr...
Next Document: Helicobacter pylori infection does not influence the efficacy of iron and vitamin B(12) fortificatio...