Document Detail

Recording respiratory parameters in patients with epilepsy.
MedLine Citation:
PMID:  19909325     Owner:  NLM     Status:  MEDLINE    
Anecdotal evidence and data from small studies suggest that respiratory changes occur in both complex partial and generalized seizures. Our understanding of sudden unexpected death in epilepsy (SUDEP) may be furthered by recording and analyzing these changes. Investigators at the Jules Thorn Telemetry Unit at the National Hospital for Neurology and Neurosurgery have documented a range of respiratory parameters (respiratory effort, airflow, oxygen saturation) in conjunction with time-locked audio-video electroencephalograms and electrocardiograms to provide a more complete picture of the physiologic changes that occur during seizures. Cardiorespiratory information on 79 seizures (70 complex partial, nine generalized) in 37 patients (20 male, 17 female) is presented. Whereas tachycardia was a common ictal feature, bradycardia was seen only rarely and tended to follow a period of apnea. Apnea occurred in 100% of generalized seizures and 39% of complex partial seizures. Apnea was predominantly central and lasted for 10-75 s (mean duration 29 s). Central apnea may be one of the major, although by no means exclusive, ictal events predisposing to SUDEP.
F Walker; D R Fish
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  38     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  1997 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S41-2     Citation Subset:  IM    
Jules Thorn Telemetry Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London, England.
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MeSH Terms
Bradycardia / diagnosis,  epidemiology
Death, Sudden / epidemiology
Electrocardiography / methods,  statistics & numerical data
Electroencephalography / methods,  statistics & numerical data
Epilepsy / diagnosis*,  epidemiology,  mortality
Epilepsy, Complex Partial / diagnosis,  epidemiology
Heart Rate / physiology
Middle Aged
Pulmonary Ventilation
Respiratory Function Tests / methods*,  statistics & numerical data
Sleep Apnea, Central / diagnosis*,  epidemiology
Tachycardia / diagnosis,  epidemiology
Telemetry / methods,  statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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