| Recording evoked potentials during deep brain stimulation: development and validation of instrumentation to suppress the stimulus artefact. | |
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MedLine Citation:
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PMID: 22510375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical efficacy of deep brain stimulation (DBS) for the treatment of movement disorders depends on the identification of appropriate stimulation parameters. Since the mechanisms of action of DBS remain unclear, programming sessions can be time consuming, costly and result in sub-optimal outcomes. Measurement of electrically evoked compound action potentials (ECAPs) during DBS, generated by activated neurons in the vicinity of the stimulating electrode, could offer insight into the type and spatial extent of neural element activation and provide a potential feedback signal for the rational selection of stimulation parameters and closed-loop DBS. However, recording ECAPs presents a significant technical challenge due to the large stimulus artefact, which can saturate recording amplifiers and distort short latency ECAP signals. We developed DBS-ECAP recording instrumentation combining commercial amplifiers and circuit elements in a serial configuration to reduce the stimulus artefact and enable high fidelity recording. We used an electrical circuit equivalent model of the instrumentation to understand better the sources of the stimulus artefact and the mechanisms of artefact reduction by the circuit elements. In vitro testing validated the capability of the instrumentation to suppress the stimulus artefact and increase gain by a factor of 1000 to 5000 compared to a conventional biopotential amplifier. The distortion of mock ECAP (mECAP) signals was measured across stimulation parameters, and the instrumentation enabled high fidelity recording of mECAPs with latencies of only 0.5 ms for DBS pulse widths of 50 to 100 µs/phase. Subsequently, the instrumentation was used to record in vivo ECAPs, without contamination by the stimulus artefact, during thalamic DBS in an anesthetized cat. The characteristics of the physiological ECAP were dependent on stimulation parameters. The novel instrumentation enables high fidelity ECAP recording and advances the potential use of the ECAP as a feedback signal for the tuning of DBS parameters. |
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Authors:
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A R Kent; W M Grill |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2012-04-18 |
Journal Detail:
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Title: Journal of neural engineering Volume: 9 ISSN: 1741-2552 ISO Abbreviation: J Neural Eng Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-25 Completed Date: 2012-09-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101217933 Medline TA: J Neural Eng Country: England |
Other Details:
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Languages: eng Pagination: 036004 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amplifiers, Electronic Animals Artifacts* Cats Computer Simulation Data Interpretation, Statistical Deep Brain Stimulation* Electric Stimulation Electronics Electrophysiology / instrumentation, methods* Evoked Potentials / physiology* Reproducibility of Results Thalamic Nuclei / physiology Thalamus / physiology |
| Grant Support | |
ID/Acronym/Agency:
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F31 NS070460/NS/NINDS NIH HHS; F31-NS070460/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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