Document Detail

Reconstruction of the radial forearm free flap donor site using integra artificial dermis.
MedLine Citation:
PMID:  20939003     Owner:  NLM     Status:  MEDLINE    
Autologous skin grafting to the donor site in patients who undergo radial forearm free flap reconstruction (RFFF) is associated with cosmetic and functional morbidity. Integra artificial dermis (Integra Lifesciences, Plainsboro, NJ) is a bovine collagen based dermal substitute that can be used as an alternative to primary autologous skin transplantation of the donor site. We describe a staged reconstruction using Integra followed by ultrathin skin grafting that results in highly aesthetic and functional outcomes for these defects. A retrospective review of 29 patients undergoing extirpative head and neck oncologic resection were examined. Integra graft placement was performed at the time of RFFF harvest followed by autologous split thickness skin grafting at 1 to 5 weeks postoperatively. Healing fully occurred within 4-6 weeks with negligible donor site complications, excellent cosmesis, and minimal scar contracture. Composite reconstruction with Integra artificial dermis offers advantages over traditional methods of coverage for select cases of radial forearm free flap donor site closures.
Ryan C Murray; Eli A Gordin; Kapil Saigal; Douglas Leventhal; Howard Krein; Ryan N Heffelfinger
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  Microsurgery     Volume:  31     ISSN:  1098-2752     ISO Abbreviation:  Microsurgery     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-06-02     Revised Date:  2011-10-14    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Department of Otolaryngology - Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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MeSH Terms
Chondroitin Sulfates*
Forearm / surgery*
Free Tissue Flaps*
Graft Survival
Head and Neck Neoplasms / surgery
Microsurgery / instrumentation,  methods
Reconstructive Surgical Procedures / adverse effects,  instrumentation*,  methods*
Retrospective Studies
Skin Transplantation / adverse effects,  instrumentation*,  methods*
Treatment Outcome
Reg. No./Substance:
0/integra artificial skin; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen
Comment In:
Microsurgery. 2011 Sep;31(6):502-4   [PMID:  21898883 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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