Document Detail


Reconstruction of the microscopic transmural edge of experimentally infarcted canine myocardium.
MedLine Citation:
PMID:  6838765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental myocardial infarction of the posterolateral left ventricular wall in 2 dog hearts, the result of 1 h of occlusion of the left circumflex coronary artery followed by 4 days of reperfusion, was studied post mortem by serial histological sectioning. Microscopic examination in a transverse plane showed a zone of apparent necrotic muscle removal which formed a continuous boundary between necrotic and normal myocardium without outlying, detached "islands" of necrosis. Reconstruction of the histological transmural edge of infarction at its interface with viable subepicardial muscle demonstrated wide overlapping and angulated interdigitation of the separated tissues across the midzone of the ventricular wall. The observed 3-dimensional spatial complexity of the transmural infarct boundary may be a limiting factor in successful evaluation of this experimentally important region.
Authors:
W N O'Connor; S R Hamann; H G Hanley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of experimental pathology     Volume:  64     ISSN:  0007-1021     ISO Abbreviation:  Br J Exp Pathol     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372543     Medline TA:  Br J Exp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Models, Anatomic
Myocardial Infarction / pathology*
Myocardium / pathology*
Necrosis
Grant Support
ID/Acronym/Agency:
RR05374/RR/NCRR NIH HHS
Comments/Corrections

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