| Recommendations for the use of medications with continuous enteral nutrition. | |
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MedLine Citation:
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PMID: 19667002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Recommendations for the use of medications with continuous enteral nutrition are provided. METHODS: A literature review was conducted to identify primary literature reporting medication interactions with continuous enteral nutrition. For medications without supporting literature, manufacturers were contacted for information. Package inserts for specific medications were also investigated for any information to help guide recommendations. If no specific recommendations were made by the pharmaceutical manufacturer or the package insert concerning administration of products with continuous enteral nutrition, a tertiary database was consulted. Recommendations were generated by a consensus of clinicians for those medications that lacked specific recommendations in the primary literature or from the pharmaceutical manufacturer. Documentation of medication interactions with continuous enteral nutrition and food was then collated along with specific recommendations on how to administer the medication with regard to continuous enteral nutrition. Recommendations were classified as strong (grade 1) or weak (grade 2). The quality of evidence was classified as high (grade A), moderate (grade B), or low (grade C). RESULTS: Forty-six medications commonly given to hospitalized patients were evaluated. Twenty-four medications had recommendations based on available data, and the remaining 22 medications had recommendations based on a consensus of clinicians. CONCLUSION: There was a lack of published data regarding drug-nutrient interactions for a majority of the drugs commonly administered to patients receiving continuous enteral nutrition. Clinicians should recognize potential drug-nutrient interactions and use available evidence to optimize patients' drug therapy. |
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Authors:
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Paul D Wohlt; Lan Zheng; Shelly Gunderson; Sarah A Balzar; Benjamin D Johnson; Jeffrey T Fish |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists Volume: 66 ISSN: 1535-2900 ISO Abbreviation: Am J Health Syst Pharm Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-10-09 Revised Date: 2010-01-05 |
Medline Journal Info:
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Nlm Unique ID: 9503023 Medline TA: Am J Health Syst Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 1458-67 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Intermountain Medical Center, 5121 South Cottonwood Street, Murray, UT 84157, USA. paul.wohlt@imail.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Incompatibility Enteral Nutrition / adverse effects* Food-Drug Interactions* Humans Pharmaceutical Preparations / administration & dosage* Practice Guidelines as Topic |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations |
| Comments/Corrections | |
Comment In:
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Am J Health Syst Pharm. 2010 Jan 1;67(1):23
[PMID:
20044363
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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