Document Detail

Recommendations on haematological criteria for the diagnosis of epoetin-induced pure red cell aplasia.
MedLine Citation:
PMID:  15522059     Owner:  NLM     Status:  MEDLINE    
Pure red cell aplasia (PRCA) is a rare condition characterised by an arrest in red blood cell production, which may be congenital or acquired. Recombinant human erythropoietin (epoetin) was introduced in 1989 for the treatment of anaemia of chronic kidney disease patients and has maintained an excellent therapeutic and safety record while treating hundreds of thousands of patients. A very rare, but serious adverse event associated with epoetin administration is a condition in which patients develop neutralising anti-erythropoietin antibodies and, consequently, PRCA. This condition is referred to as epoetin-induced PRCA (epo-PRCA). Since it is a rare condition, many haematologists and nephrologists around the world see the condition infrequently and may be uncertain about the diagnosis. For this reason, an ad hoc international working group of expert haematologists and nephrologists met together to derive new recommendations for the haematological diagnosis of epo-PRCA. These recommendations, which represent the consensus opinions of the working group, address haematological approaches to monitor and investigate suspected epo-PRCA and should help physicians differentiate between PRCA and other bone marrow diseases, as well as, between PRCA and epo-PRCA.
Nicole Casadevall; Denis Cournoyer; Judith Marsh; Hans Messner; Chris Pallister; John Parker-Williams; Jérôme Rossert
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Publication Detail:
Type:  Consensus Development Conference; Guideline; Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of haematology     Volume:  73     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
Service d'Hematologie Biologique, Hôpital Hôtel-Dieu, Paris, France.
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MeSH Terms
Autoantibodies / immunology
Blood Cell Count
Bone Marrow Examination / methods
Epoetin Alfa / adverse effects*
Erythropoietin / immunology
Hematopoietic Stem Cells / pathology
Hemoglobins / analysis
Practice Guidelines as Topic
Red-Cell Aplasia, Pure / blood,  chemically induced*,  diagnosis
Reg. No./Substance:
0/Autoantibodies; 0/Hemoglobins; 11096-26-7/Erythropoietin; 113427-24-0/Epoetin Alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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