Document Detail

Recombined bone xenografts enhance tendon graft osteointegration of anterior cruciate ligament reconstruction.
MedLine Citation:
PMID:  19184009     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to discover whether recombined bone xenograft (RBX), a porous solid material, could augment healing of the tendon-to-bone interface after anterior cruciate ligament (ACL) reconstruction. ACL reconstruction was performed bilaterally in 25 skeletally mature rabbits using long digital extensor tendon grafts. RBX was implanted into the treated knee, with the contralateral knee serving as control. Three rabbits were killed at postoperative weeks two, six and 12 for routine histology. The remaining 16 rabbits were killed at weeks six and 12, and their femur-graft-tibia complexes were harvested for mechanical testing. The treatment and control groups produced different histological findings at the interface between the tendon and bone. In the treatment group, large areas of chondrocyte-like cells were noted around the tendon-bone interface two weeks after the operation. At six weeks, more abundant bone formation was observed around the tendon. At 12 weeks, an immature neoenthesis structure was seen. In biomechanical evaluation six and 12 weeks after the operation, the ultimate strength of tendon in the bone tunnel was significantly higher in the treatment group than in the control group. RBX can augment the osteointegration of tendon to bone after ACL reconstruction.
Weimin Pan; Yunyu Hu; Yiyong Wei; Long Bi; Dan Li; Jun Wang; Rong Lv; Jianwei Li; Zheng Cao
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Publication Detail:
Type:  Journal Article     Date:  2009-01-29
Journal Detail:
Title:  International orthopaedics     Volume:  33     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2010-03-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1761-8     Citation Subset:  IM    
Institute of Orthopaedics and Traumatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
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MeSH Terms
Anterior Cruciate Ligament / physiology,  surgery*
Bone Transplantation / methods*
Femur / pathology,  physiology,  surgery
Models, Animal
Osteogenesis / physiology*
Tendon Transfer / methods*
Tendons / pathology,  physiology,  surgery
Tibia / pathology,  physiology,  surgery
Transplantation, Heterologous
Wound Healing / physiology

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