| Recombination proteins mediate meiotic spatial chromosome organization and pairing. | |
| | |
MedLine Citation:
|
PMID: 20371348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Meiotic chromosome pairing involves not only recognition of homology but also juxtaposition of entire chromosomes in a topologically regular way. Analysis of filamentous fungus Sordaria macrospora reveals that recombination proteins Mer3, Msh4, and Mlh1 play direct roles in all of these aspects, in advance of their known roles in recombination. Absence of Mer3 helicase results in interwoven chromosomes, thereby revealing the existence of features that specifically ensure "entanglement avoidance." Entanglements that remain at zygotene, i.e., "interlockings," require Mlh1 for resolution, likely to eliminate constraining recombinational connections. Patterns of Mer3 and Msh4 foci along aligned chromosomes show that the double-strand breaks mediating homologous alignment have spatially separated ends, one localized to each partner axis, and that pairing involves interference among developing interhomolog interactions. We propose that Mer3, Msh4, and Mlh1 execute all of these roles during pairing by modulating the state of nascent double-strand break/partner DNA contacts within axis-associated recombination complexes. |
| | |
Authors:
|
Aurora Storlazzi; Silvana Gargano; Gwenael Ruprich-Robert; Matthieu Falque; Michelle David; Nancy Kleckner; Denise Zickler |
Related Documents
:
|
19099188 - Chromatin structure contribution to the synaptonemal complex formation. 8243168 - Two new x-autosome robertsonian translocations in the mouse. ii. sex chromosome configu... 10101178 - Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent l... 10973068 - The pachytene checkpoint. 18266248 - Array comparative genomic hybridization (acgh) analysis in prader-willi syndrome. 17253988 - The fluorouridine insensitive 1 (fur1) mutant is defective in equilibrative nucleoside ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cell Volume: 141 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-07 Completed Date: 2010-04-22 Revised Date: 2011-07-27 |
Medline Journal Info:
|
Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 94-106 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Institut de Génétique et Microbiologie, UMR 8621, Université Paris-Sud, 91405 Orsay, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle Proteins
/
metabolism* Chromosome Pairing* Fungal Proteins / metabolism* Meiosis* Sordariales / cytology*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
GM025326/GM/NIGMS NIH HHS; GM044794/GM/NIGMS NIH HHS; R01 GM025326-28/GM/NIGMS NIH HHS; R01 GM025326-29/GM/NIGMS NIH HHS; R01 GM025326-33/GM/NIGMS NIH HHS; R01 GM044794-19/GM/NIGMS NIH HHS; R01 GM044794-20S1/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cell Cycle Proteins; 0/Fungal Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Persistent telomere damage induces bypass of mitosis and tetraploidy.
Next Document: Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-c...