Document Detail


Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates.
MedLine Citation:
PMID:  18385248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can partially protect macaques after challenge with Zaire ebolavirus. Here, we administered a VSV vector expressing the Sudan ebolavirus (SEBOV) glycoprotein to four rhesus macaques shortly after exposure to SEBOV. All four animals survived SEBOV challenge, while a control animal that received a nonspecific vector developed fulminant SEBOV hemorrhagic fever and succumbed. This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses.
Authors:
Thomas W Geisbert; Kathleen M Daddario-DiCaprio; Kinola J N Williams; Joan B Geisbert; Anders Leung; Friederike Feldmann; Lisa E Hensley; Heinz Feldmann; Steven M Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-04-02
Journal Detail:
Title:  Journal of virology     Volume:  82     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-06-11     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5664-8     Citation Subset:  IM    
Affiliation:
National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA. geisbert@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Ebolavirus / physiology*
Genetic Vectors / genetics*
Hemorrhagic Fever, Ebola / genetics,  metabolism*,  prevention & control*
Macaca mulatta / blood,  virology*
Survival Rate
Vesiculovirus / genetics*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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