| Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge. | |
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MedLine Citation:
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PMID: 3184276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice immunized with recombinant vaccinia virus (VACC) expressing Venezuelan equine encephalitis (VEE) virus capsid protein and glycoproteins E1 and E2 or with attenuated VEE TC-83 virus vaccine developed VEE-specific neutralizing antibody and survived intraperitoneal challenge with virulent VEE virus strains including Trinidad donkey (subtype 1AB), P676 (subtype 1C), 3880 (subtype 1D), and Everglades (subtype 2). However, unlike immunization with TC-83 virus, immunization with the recombinant VACC/VEE virus did not protect mice from intranasal challenge with VEE Trinidad donkey virus. These results suggest that recombinant VACC/VEE virus is a vaccine candidate for equines and humans at risk of mosquito-transmitted VEE disease but not for laboratory workers at risk of accidental exposure to aerosol infection with VEE virus. |
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Authors:
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R M Kinney; J J Esposito; J H Mathews; B J Johnson; J T Roehrig; A D Barrett; D W Trent |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of virology Volume: 62 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1988-12-20 Completed Date: 1988-12-20 Revised Date: 2013-03-26 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4697-702 Citation Subset: IM |
Affiliation:
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Division of Vector-Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522-2087. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / biosynthesis Capsid / immunology Cross Reactions Encephalitis Virus, Venezuelan Equine / genetics, immunology* Encephalomyelitis, Equine / prevention & control* Encephalomyelitis, Venezuelan Equine / prevention & control* Enzyme-Linked Immunosorbent Assay Female Glycoproteins / immunology Hemagglutination Inhibition Tests Male Mice Mice, Inbred Strains Neutralization Tests Vaccines* / immunology Vaccines, Attenuated Vaccines, Synthetic* / immunology Vaccinia virus / genetics, immunology Viral Vaccines* / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Glycoproteins; 0/Vaccines; 0/Vaccines, Attenuated; 0/Vaccines, Synthetic; 0/Viral Vaccines |
| Comments/Corrections | |
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