| Recombinant tissue plasminogen activator in acute myocardial infarction in the Chinese in Hong Kong. | |
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MedLine Citation:
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PMID: 1512055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighty-nine consecutive Chinese patients (69 males, 20 females) with acute myocardial infarction treated by 100 mg recombinant tissue plasminogen activator (7 intracoronarily, 82 intravenously) at 3.7 +/- 1.0 h after onset, and intravenous heparin or dipyridamole therapy started at 3 h, were studied prospectively. Their mean age was 59.6 +/- 10.6 yr. Forty-six patients (51.7%) had anterior and 39 patients (43.8%) had inferior infarcts. Clinical evidence of reperfusion were seen in 63 patients (70.8%), while new complications included hypotension (5.6%), heart failure (6.7%), cardiac arrhythmias (76.4%) majority of which are related to reperfusion and self-remitting, haematoma around vascular access sites (23.6%), melaena (3.3%) and cerebral infarction (2.2%). Maximal changes in coagulation profiles were seen at 3 h, including a decrease in fibrinogen by 64.2% and an increase in fibrin degradation products by 47 times. The changes in haemostatic variables were not related to body weight or bleeding complications. Nine patients (10.1%) had recurrence of angina and 6 patients (6.9%) died due to pump failure and reinfarction. Angiogram at 14 days confirmed TIMI 2 or 3 patency of infarct-related arteries in 63 out of 73 (86.3%) patients, with a mean global ejection fraction of 52.5 +/- 12.4%. Nearly all survivors could maintain class I-II functional status after discharge. The safety and promise of recombinant tissue plasminogen activator for acute myocardial infarction in the Chinese were confirmed. |
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Authors:
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K S Woo; K K Tse; Y K Mak; H K Chung; C Y Tse |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 36 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-01 Completed Date: 1992-10-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Affiliation:
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Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Asian Continental Ancestry Group Blood Coagulation Tests Coronary Vessels Dipyridamole / administration & dosage Female Heparin / administration & dosage Hong Kong / ethnology Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction / blood, drug therapy* Tissue Plasminogen Activator / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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58-32-2/Dipyridamole; 9005-49-6/Heparin; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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