Document Detail


Recombinant protein polymers in biomaterials.
MedLine Citation:
PMID:  23276922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Naturally occurring protein-based materials have been found that function as critical components in biomechanical response, fibers and adhesives. A relatively small but growing number of recombinant protein-based materials that mimic the desired features of their natural sources, such as collagens, elastins and silks, are considered as an alternative to conventional synthetic polymers. Advances in genetic engineering have facilitated the synthesis of repetitive protein polymers with precise control of molecular weights which are designed by using synthetic genes encoding tandem repeats of oligopeptide originating from a modular domain of natural proteins. Many repeat sequences as protein polymer building blocks adopt a well-defined secondary structure and undergo self-assembly to result in physically cross-linked networks or with chemical cross-linking so that further form three-dimensional architectures similar to natural counterparts. In this review, recombinant protein polymers currently developed will be presented that have emerged as promising class of next generation biomaterials.
Authors:
Wookhyun Kim
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-304     Citation Subset:  IM    
Affiliation:
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. wkim2@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemical synthesis*,  chemistry
Biomimetic Materials / chemical synthesis
Collagen / chemistry
Elastin / chemistry
Elastomers
Insect Proteins / chemistry
Protein Engineering / methods
Protein Structure, Tertiary
Proteins / chemistry
Recombinant Proteins*
Repetitive Sequences, Amino Acid
Silk / chemistry
Spiders
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Elastomers; 0/Insect Proteins; 0/Proteins; 0/Recombinant Proteins; 0/Silk; 0/adhesive protein, mussel; 61790-52-1/resilin; 9007-34-5/Collagen; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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