Document Detail


Recombinant inbred and congenic strains for mapping of genes that are responsible for spontaneous hypertension and other risk factors of cardiovascular disease.
MedLine Citation:
PMID:  8997635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spontaneously hypertensive rat (SHR) is the most widely used animal model of human essential hypertension. In the SHR strain, as in humans, the high blood pressure is determined multifactorially. Analysis of genetically segregating populations, derived from SHR and normotensive inbred strains, enabled localization of quantitative trait loci (QTLs) responsible for blood pressure regulation on several rat chromosomes. Analysis of specialized strains, congenic and recombinant inbred (RI) strains, helped to analyze some of these mapping results in detail: (1) analysis of congenic strains provided definitive evidence for the presence of blood pressure regulatory genes on chromosomes 8 and 13 and will enable mapping of responsible genes to limited segments of differential chromosomes, (2) the RI strains were shown to be especially useful for genome scanning studies of complex traits and for correlation analysis of blood pressure and other risk factors of cardiovascular disease such as cardiac hypertrophy, dyslipidemia, and insulin resistance.
Authors:
V Kren; D Krenová; V Bílá; M Zdobinská; V Zídek; M Pravenec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia biologica     Volume:  42     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
1st Medical Faculty, Charles University, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / genetics
Cardiovascular Diseases / genetics*
Chromosome Mapping*
Hyperlipidemias / genetics
Hypertension / genetics*
Inbreeding
Insulin Resistance / genetics
Rats
Rats, Inbred SHR
Recombination, Genetic*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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