Document Detail

Recombinant in vitro tools to predict drug metabolism and safety.
MedLine Citation:
PMID:  10707045     Owner:  NLM     Status:  Publisher    
Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalysed by drug metabolizing enzymes. Prediction of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetic properties of candidate drugs in humans.
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Publication Detail:
Journal Detail:
Title:  Pharmaceutical science & technology today     Volume:  3     ISSN:  -     ISO Abbreviation:  Pharm. Sci. Technol. Today     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9892156     Medline TA:  Pharm Sci Technolo Today     Country:  -    
Other Details:
Languages:  ENG     Pagination:  99-105     Citation Subset:  -    
Biomedical Research Centre,Ninewells Hospital and Medical School, Ninewells Hospital, Dundee, UK DD1 9SY.
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