Document Detail


Recombinant in vitro tools to predict drug metabolism and safety.
MedLine Citation:
PMID:  10707045     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalysed by drug metabolizing enzymes. Prediction of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetic properties of candidate drugs in humans.
Authors:
Friedberg
Related Documents :
16970545 - Aldo-keto reductases and bioactivation/detoxication.
872925 - Isolation and identification of two hydroxylated metabolites of phenazopyridine in rat ...
16819505 - Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoco...
3086535 - Effects of dietary fat on drug metabolism.
2324865 - Correlates of persisting drug use among former youth multiple drug abuse patients.
16480505 - Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involvin...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Pharmaceutical science & technology today     Volume:  3     ISSN:  -     ISO Abbreviation:  Pharm. Sci. Technol. Today     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9892156     Medline TA:  Pharm Sci Technolo Today     Country:  -    
Other Details:
Languages:  ENG     Pagination:  99-105     Citation Subset:  -    
Affiliation:
Biomedical Research Centre,Ninewells Hospital and Medical School, Ninewells Hospital, Dundee, UK DD1 9SY.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Advances in the use of monoclonal antibodies in cancer radiotherapy.
Next Document:  Monitor: progress and profiles.