| Recombinant human thyrotropin-aided radioiodine therapy in patients with metastatic differentiated thyroid carcinoma. | |
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MedLine Citation:
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PMID: 21876838 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Our aim was to test the efficacy of 131-I therapy (RIT) using recombinant human TSH (rhTSH) in patients with differentiated thyroid carcinoma (DTC) in whom endogenous TSH stimulation was not an option due to the poor patient's physical condition or due to the disease progression during L-thyroxin withdrawal. The study comprised 18 patients, who already have undergone total or near-total thyroidectomy and radioiodine ablation and 0-12 (median 5) RITs after L-thyroxin withdrawal. Our patients received altogether 44 RITs using rhTSH while on L-thyroxin. Six to 12 months after the first rhTSH-aided RIT, PR and SD was achieved in 3/18 (17%) and 4/18 patients (22%), respectively. In most patients (n = 12; 61%) disease progressed despite rhTSH-aided RITs. As a conclusion, rhTSH-aided RIT proved to add some therapeutic benefit in 39% our patients with metastatic DTC, who otherwise could not be efficiently treated with RIT. |
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Authors:
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Ivana Zagar; Andreja A Schwarzbartl-Pevec; Barbara Vidergar-Kralj; Rika Horvat; Nikola Besic |
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Publication Detail:
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Type: Journal Article Date: 2011-08-18 |
Journal Detail:
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Title: Journal of thyroid research Volume: 2012 ISSN: 2042-0072 ISO Abbreviation: J Thyroid Res Publication Date: 2012 |
Date Detail:
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Created Date: 2011-08-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536655 Medline TA: J Thyroid Res Country: United States |
Other Details:
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Languages: eng Pagination: 670180 Citation Subset: - |
Affiliation:
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Department of Nuclear Medicine, Institute of Oncology, 1000 Ljubljana, Slovenia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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