Document Detail

Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against Aspergillus fumigatus.
MedLine Citation:
PMID:  11500084     Owner:  NLM     Status:  MEDLINE    
The in vivo and ex vivo effects of macrophage colony-stimulating factor (M-CSF) were studied in a profoundly neutropenic rabbit model in order to determine its potential to augment pulmonary host defence against Aspergillus. M-CSF (100-600 microg/kg/d) was administered prophylactically to neutropenic rabbits with pulmonary aspergillosis starting three days pre-inoculation and then throughout neutropenia. Rabbits receiving M-CSF had significantly increased survival (P=0.01) and decreased pulmonary injury, as measured by decreased pulmonary infarction (P=0.004), when compared with untreated controls. Microscopic studies demonstrated greater numbers of activated pulmonary alveolar macrophages (PAMs) in lung tissue of rabbits receiving M-CSF, in comparison to controls (P<0.001). PAMs harvested from rabbits treated with M-CSF had a significantly greater percent phagocytosis of Aspergillus fumigatus conidia than did PAMs from controls (P=0.04). These data indicate that prophylactic administration of M-CSF augments pulmonary host defence against A. fumigatus and suggest a potential role for this cytokine as adjunctive therapy in the treatment of pulmonary aspergillosis in the setting of profound neutropenia.
C E Gonzalez; C A Lyman; S Lee; C Del Guercio; E Roilides; J Bacher; A Gehrt; E Feuerstein; M Tsokos; T J Walsh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytokine     Volume:  15     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-13     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-95     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
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MeSH Terms
Antifungal Agents / pharmacology*
Aspergillosis / drug therapy*,  immunology,  pathology
Aspergillus fumigatus / drug effects
Lung Diseases, Fungal / drug therapy*,  immunology,  pathology
Macrophage Colony-Stimulating Factor / pharmacology*
Macrophages / immunology
Phagocytosis / drug effects,  immunology
Pneumonia / drug therapy,  microbiology,  pathology
Pulmonary Alveoli / pathology
Pulmonary Embolism / drug therapy,  pathology
Recombinant Proteins
Survival Rate
Reg. No./Substance:
0/Antifungal Agents; 0/Recombinant Proteins; 81627-83-0/Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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