Document Detail

Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans.
MedLine Citation:
PMID:  15741245     Owner:  NLM     Status:  MEDLINE    
The present study examined the role of the cytokine IL-6 in the regulation of fatty acid metabolism during exercise in humans. Six well-trained males completed three trials of 120 min of cycle ergometry at 70% peak O(2) consumption (Vo(2 peak); MOD) and 40% Vo(2 peak) with (LOW + IL-6) and without (LOW) infusion of recombinant human (rh)IL-6. The dose of rhIL-6 during LOW + IL-6 elicited IL-6 concentration similar to those during MOD but without altering the circulating hormonal milieu seen in MOD. Palmitate rate of appearance (R(a)), rate of disappearance (R(d)), and oxidation were measured by means of a constant infusion of [U-(13)C]palmitate (0.015, prime NaHCO(3), 1 micromol/kg). Palmitate R(a), R(d), and oxidation were not affected by rhIL-6 infusion, remaining similar to LOW at all times. Palmitate R(a) and oxidation were significantly greater in the MOD trial (P < 0.05) compared with the LOW + IL-6 and LOW trials. Our data show that a low dose of rhIL-6, administered during low-intensity exercise without altering the hormonal milieu, does not alter fatty acid metabolism. These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6.
N Hiscock; C P Fischer; M Sacchetti; G van Hall; M A Febbraio; B K Pedersen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-01
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  289     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-16     Completed Date:  2005-07-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E2-7     Citation Subset:  IM    
The Copenhagen Muscle Research Center, Rigshospitalet, Denmark.
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MeSH Terms
Fatty Acids / metabolism*
Infusions, Intra-Arterial
Interleukin-6 / administration & dosage*,  blood*
Lipolysis / physiology*
Oxygen / metabolism*
Oxygen Consumption / physiology*
Physical Exertion / physiology*
Recombinant Proteins / administration & dosage,  blood
Reg. No./Substance:
0/Fatty Acids; 0/Interleukin-6; 0/Recombinant Proteins; 7782-44-7/Oxygen

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