Document Detail


Recombinant human growth hormone treatment of children following renal transplantation.
MedLine Citation:
PMID:  2025525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine growth-retarded renal allograft recipients received either thrice weekly or daily subcutaneous recombinant human growth hormone (rhGH) for 6-30 months. The annualized growth velocity for the initial year of rhGH treatment was significantly greater than that of the preceding year (2.5 +/- 2.1 vs 5.7 +/- 2.7; P less than 0.0001). There was no advancement in bone age greater than the increase in chronological age, no significant increase in the mean fasting serum glucose or insulin levels, nor significant decrease in the calculated creatinine clearance following rhGH treatment. However, two patients experienced rejection episodes following rhGH treatment indicating the potential adverse consequences of the treatment on allograft function. This will require further delineation in prospective controlled studies. The serum insulin-like growth factor-1 levels significantly increased at 6 months (P less than 0.009) and 12 months (P less than 0.002) following rhGH treatment compared with baseline values. These preliminary data indicate that rhGH treatment may be effective in improving the growth velocity of growth-retarded renal allograft recipients.
Authors:
R N Fine; O Yadin; P A Nelson; K Pyke-Grimm; M I Boechat; B H Lippe; B M Sherman; R B Ettenger; E Kamil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  5     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-12     Completed Date:  1991-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, UCLA Center for the Health Sciences 90024.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Glucose / analysis
Child
Child, Preschool
Female
Graft Rejection
Growth Disorders / drug therapy*
Growth Hormone / therapeutic use*
Humans
Kidney Transplantation / adverse effects*
Male
Recombinant Proteins / therapeutic use
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Recombinant Proteins; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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