Document Detail


Recombinant human granulocyte-macrophage colony-stimulating factor hydrogel promotes healing of deep partial thickness burn wounds.
MedLine Citation:
PMID:  22652468     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To assess the effects of recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) hydrogel on the healing of deep partial thickness burn wounds. METHODS: Ninety three wounds of 65 burn patients who suffered from a deep partial thickness burn of <5% TBSA and could not heal over 3weeks were included in this study. The patients were randomly assigned to use rhGM-CSF hydrogel (GC group, n=32) or hydrogel without rhGM-CSF (control group, n=33). rhGM-CSF hydrogel or hydrogel without rhGM-CSF was topically applied to the wounds, the dressing was changed once a day. Wound healing time and percentage, wound discharge, periwound inflammation, the positive wound swabs culture count, and adverse drug reactions were observed and compared between two groups. RESULTS: Healing time was 12.2±5.0days after the application of rhGM-CSF hydrogel. This was significantly shorter than that of control wounds (15.5±4.7days). Healing percentage at 14days in the rhGM-CSF-treated wounds was 97.5±7.7%, which was markedly higher than the control (85.9±6.8%). At 3, 6, 12, 14day, the GC group was significantly superior to the control group with respect to the score of periwound inflammation, wound purulence and discharge. The positive wound swabs culture count of the GC group on the 7th and 14th day post-treatment was 14 and 4, respectively, which was significantly lower than the control. CONCLUSION: rhGM-CSF hydrogel promotes the healing process of deep partial thickness burns effectively. No adverse reaction of the drug was observed during the study.
Authors:
Hong Yan; Jian Chen; Xi Peng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  -     ISSN:  1879-1409     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.
Affiliation:
Institute of Burn Research, South-west Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, PR China.
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