Document Detail


Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  9659643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy and safety of recombinant human erythropoietin (rHuEPO) in very low birth weight infants with anemia of prematurity. STUDY DESIGN: Thirty infants were randomly assigned to receive either rHuEPO (300 U/kg per dose) or placebo twice a week. Hematologic parameters, transfusion requirements, caloric intake, and growth were monitored. RESULTS: The number and volume of erythrocyte transfusions were significantly lower in infants treated with rHuEPO. Serum ferritin levels, similar in both groups at study entry, fell and were significantly lower in rHuEPO-group infants at the completion of the study. An inverse correlation was observed between reticulocyte count and absolute neutrophil count both at entry and at completion of the study. CONCLUSION: Twice-a-week administration of rHuEPO significantly reduces the need for erythrocyte transfusion in very low birth weight infants in stable condition. A significant decrease in serum ferritin levels in infants receiving rHuEPO suggests the need to determine the optimal dose of iron supplementation in these infants.
Authors:
P Kumar; S Shankaran; R G Krishnan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  18     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-09-24     Completed Date:  1998-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hutzel Hospital, Wayne State University School of Medicine, Detroit, Mich., USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Neonatal / blood,  therapy*
Blood Cell Count
Double-Blind Method
Erythrocyte Transfusion
Erythropoietin / therapeutic use*
Female
Ferritins / blood
Humans
Infant
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature*
Male
Neutrophils / pathology
Placebos
Recombinant Proteins
Reticulocyte Count
Chemical
Reg. No./Substance:
0/Placebos; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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