| Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 9659643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy and safety of recombinant human erythropoietin (rHuEPO) in very low birth weight infants with anemia of prematurity. STUDY DESIGN: Thirty infants were randomly assigned to receive either rHuEPO (300 U/kg per dose) or placebo twice a week. Hematologic parameters, transfusion requirements, caloric intake, and growth were monitored. RESULTS: The number and volume of erythrocyte transfusions were significantly lower in infants treated with rHuEPO. Serum ferritin levels, similar in both groups at study entry, fell and were significantly lower in rHuEPO-group infants at the completion of the study. An inverse correlation was observed between reticulocyte count and absolute neutrophil count both at entry and at completion of the study. CONCLUSION: Twice-a-week administration of rHuEPO significantly reduces the need for erythrocyte transfusion in very low birth weight infants in stable condition. A significant decrease in serum ferritin levels in infants receiving rHuEPO suggests the need to determine the optimal dose of iron supplementation in these infants. |
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Authors:
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P Kumar; S Shankaran; R G Krishnan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 18 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 1998 May-Jun |
Date Detail:
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Created Date: 1998-09-24 Completed Date: 1998-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hutzel Hospital, Wayne State University School of Medicine, Detroit, Mich., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Neonatal
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blood,
therapy* Blood Cell Count Double-Blind Method Erythrocyte Transfusion Erythropoietin / therapeutic use* Female Ferritins / blood Humans Infant Infant, Low Birth Weight* Infant, Newborn Infant, Premature* Male Neutrophils / pathology Placebos Recombinant Proteins Reticulocyte Count |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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