Document Detail


Recombinant human erythropoietin has no direct or strong vasoconstrictor effects in vivo and in vitro.
MedLine Citation:
PMID:  7566609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An elevation of blood pressure is observed in approximately 30% of dialysis patients treated with recombinant human erythropoietin (rHuEPO). Various studies have been performed in order to elucidate possible underlying mechanisms, but it is not yet well understood whether there is one major mechanism involved. In this present study, samples were obtained from male normotensive Wistar-Kyoto rats (WKY) and genetically hypertensive rats (SHR) at the age of 5 and 20 weeks. Thoracic aorta rings, with or without endothelium, isolated from WKY and SHR were used to evaluate the direct effect of rHuEPO on vascular smooth muscle by measuring the tension of vascular smooth muscle induced by various concentrations (1-100 IU/ml) of rHuEPO. Also, rHuEPO (10, 100, 1000 and 10,000 IU/kg) was intravenously administrated and the changes in mean blood pressure were recorded for 5-10 min. rHuEPO produced no significant contraction in the rat aortae in any of the preparation studies, in the presence or the absence of endothelium. The intravenous administration of rHuEPO had no immediate effect on mean blood pressure in 5- and 20-week-old WKY and SHR. These results suggest that the elevation of blood pressure observed in the clinical setting following the administration of rHuEPO is not due to a direct pressor effect on vascular smooth muscle.
Authors:
S Takahashi; M Yanai; K Okada
Related Documents :
11751729 - Isolated systolic hypertension in elderly wky is reversed with l-arginine and ace inhib...
9072379 - Acceleration of renal disease in obese shr by exacerbation of hypertension.
2978739 - Effect of antihypertensive therapy on the cardiovascular amplifiers.
7768569 - Analysis of the role of angiotensinogen in spontaneous hypertension.
12600899 - Gene transfer of extracellular superoxide dismutase reduces arterial pressure in sponta...
16612249 - Middle cerebral artery structure and distensibility during developing and established p...
15894899 - Acute pressure-natriuresis function shows early impairment in lyon hypertensive rats.
1328369 - Familial influence upon nacl sensitivity in patients with essential hypertension.
25244269 - Clinical and laboratory findings in mad honey poisoning: a single center experience.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  10     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-01     Completed Date:  1995-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  815-20     Citation Subset:  IM    
Affiliation:
Nishi-Kofu National Hospital, Yamanashi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta
Blood Pressure / drug effects*
Disease Models, Animal
Erythropoietin / administration & dosage*
Hypertension / physiopathology*
Infusions, Intravenous
Male
Muscle, Smooth, Vascular / drug effects*,  physiology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of diagnostic criteria for analgesic nephropathy in patients with end-stage renal failure...
Next Document:  Correction of chronic metabolic acidosis in haemodialysed patients by acetate-free biofiltration doe...