Document Detail


Recombinant human bone morphogenic protein-2 in fracture care.
MedLine Citation:
PMID:  16479219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recombinant human bone morphogenic protein-2 (rhBMP-2) is an osteoinductive protein that is now available for the acute treatment of open tibial fracture. Data from preclinical and clinical trials support its role in fracture care. This article summarizes data from two randomized controlled clinical trials investigating the safety and efficacy of rhBMP-2 in patients with open tibial shaft fractures and tibial fractures with bone defects. Also included is a summary of an economic analysis that examined the cost impact of rhBMP-2 from a hospital and payor perspective.
Authors:
Alan L Jones
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  19     ISSN:  0890-5339     ISO Abbreviation:  J Orthop Trauma     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S23-5     Citation Subset:  IM    
Affiliation:
Baylor University Medical Center at Dallas, Dallas, TX 75246-1800, USA. AlanJ@BaylorHealth.edu
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MeSH Terms
Descriptor/Qualifier:
Bone Morphogenetic Proteins / economics,  therapeutic use*
Cost-Benefit Analysis
Fracture Healing / drug effects*
Fractures, Open / drug therapy*,  surgery
Humans
Recombinant Proteins / therapeutic use
Tibial Fractures / drug therapy*,  surgery
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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