Document Detail

Recombinant human bone morphogenic protein-2 in fracture care.
MedLine Citation:
PMID:  16479219     Owner:  NLM     Status:  MEDLINE    
Recombinant human bone morphogenic protein-2 (rhBMP-2) is an osteoinductive protein that is now available for the acute treatment of open tibial fracture. Data from preclinical and clinical trials support its role in fracture care. This article summarizes data from two randomized controlled clinical trials investigating the safety and efficacy of rhBMP-2 in patients with open tibial shaft fractures and tibial fractures with bone defects. Also included is a summary of an economic analysis that examined the cost impact of rhBMP-2 from a hospital and payor perspective.
Alan L Jones
Related Documents :
18449129 - Bilateral stress fracture of distal fibula and tibia--case report.
24276109 - Pseudoarthrosis and fracture: interaction between severe vitamin d deficiency and prima...
20454779 - The accuracy of intramedullary tibial guide of sagittal alignment of pcl-substituting t...
23685349 - A.s.p.e.n. clinical guidelines: nutrition support of neonatal patients at risk for meta...
20386289 - Compaction bone grafting in tibial plateau fracture fixation.
19043129 - A trabecular metal tibial component in total knee replacement in patients younger than ...
2355029 - The osteo-anconeus flap. an approach for total elbow arthroplasty.
20516629 - Biological underpinnings of frost's mechanostat thresholds: the important role of osteo...
3577739 - Incidence of hip fracture in western sweden 1974-1982. comparison of rural and urban po...
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of orthopaedic trauma     Volume:  19     ISSN:  0890-5339     ISO Abbreviation:  J Orthop Trauma     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807705     Medline TA:  J Orthop Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S23-5     Citation Subset:  IM    
Baylor University Medical Center at Dallas, Dallas, TX 75246-1800, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Morphogenetic Proteins / economics,  therapeutic use*
Cost-Benefit Analysis
Fracture Healing / drug effects*
Fractures, Open / drug therapy*,  surgery
Recombinant Proteins / therapeutic use
Tibial Fractures / drug therapy*,  surgery
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bone morphogenic protein science and studies.
Next Document:  Recombinant human bone morphogenic protein-7: applications for clinical trauma.