Document Detail

Recombinant factor VIIa to treat bleeding after cardiac surgery in an infant.
MedLine Citation:
PMID:  12656542     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors present the use of synthetic factor VIIa to treat bleeding after cardiopulmonary bypass and surgical repair of an atrial septal defect in an infant with trisomy 10 and pulmonary hypertension. DESIGN: Case report. SETTING: University-affiliated pediatric intensive care unit. PATIENTS: A 4-mo-old, 3.7-kg infant. MAIN RESULTS: After a single dose of synthetic factor VIIa, there was normalization of the prothrombin and partial thromboplastin time and cessation of bleeding. CONCLUSION: The potential benefits of synthetic factor VIIa when compared with conventional therapy with fresh frozen plasma are discussed. Previous experience with synthetic factor VIIa in pediatric-aged patients and the cardiothoracic surgical population is presented.
Joseph D Tobias; John W Berkenbosch; Pierantonio Russo
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  4     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-05-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
Department of Anesthesiology, University of Missouri, Columbia, MO, USA.
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MeSH Terms
Cardiopulmonary Bypass
Factor VIIa / therapeutic use*
Heart Defects, Congenital / surgery*
Heart Septal Defects, Atrial / surgery*
Hemorrhage / drug therapy*,  etiology
Partial Thromboplastin Time
Prothrombin Time
Reg. No./Substance:

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