| Recombinant elastin-mimetic biomaterials: Emerging applications in medicine. | |
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MedLine Citation:
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PMID: 20441783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biomaterials derived from protein-based block copolymers are increasingly investigated for potential application in medicine. In particular, recombinant elastin block copolymers provide significant opportunities to modulate material microstructure and can be processed in various forms, including particles, films, gels, and fiber networks. As a consequence, biological and mechanical responses of elastin-based biomaterials are tunable through precise control of block size and amino acid sequence. In this review, the synthesis of a set of elastin-mimetic triblock copolymers and their diverse processing methods for generating material platforms currently applied in medicine will be discussed. |
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Authors:
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Wookhyun Kim; Elliot L Chaikof |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-05-02 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 62 ISSN: 1872-8294 ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-10 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1468-78 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, 30332, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Biomimetic Materials / chemistry* Elastin / chemistry* Humans Protein Engineering / methods* Recombinant Proteins / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL056819-13/HL/NHLBI NIH HHS; R01 HL060464-09/HL/NHLBI NIH HHS; R01 HL083867-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Recombinant Proteins; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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