| Recombinant activated factor VII in cardiac surgery: a systematic review. | |
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MedLine Citation:
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PMID: 17258029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postoperative hemorrhage is a common complication in cardiac surgery, and it is associated with a considerable increase in morbidity, mortality, and cost. Recombinant activated factor VII (rFVIIa) is an emerging hemostatic agent, increasingly used in cardiac surgery. This article systematically reviews the evidence regarding the efficacy, safety, and cost of rFVIIa in this setting. Although definitive evidence from randomized controlled trials is lacking, the use of rFVIIa in patients experiencing refractory postoperative hemorrhage seems promising and relatively safe. However further research is required to definitively establish its clinical utility in the postoperative cardiac patient. |
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Authors:
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Oliver Warren; Kaushik Mandal; Vassilis Hadjianastassiou; Lisa Knowlton; Sukhmeet Panesar; Kokotsakis John; Ara Darzi; Thanos Athanasiou |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 83 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-29 Completed Date: 2007-03-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 707-14 Citation Subset: AIM; IM |
Affiliation:
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Department of BioSurgery and Surgical Technology, Imperial College Faculty of Medicine, St. Mary's Hospital, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures* Drug Costs Factor VII / adverse effects, economics, therapeutic use* Factor VIIa Hemorrhage / drug therapy, prevention & control Hemostasis, Surgical / methods* Humans Recombinant Proteins / adverse effects, economics, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 0/recombinant FVIIa; 9001-25-6/Factor VII; EC 3.4.21.21/Factor VIIa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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