| Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer. | |
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MedLine Citation:
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PMID: 22241718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cytotoxic anticancer treatment may induce amenorrhea or menopause to a variable extent. These side-effects may not only impair or impede fertility, but also cause sexual dysfunction, bone loss and menopausal symptoms, with a strikingly negative effect on quality of life in many women. Aromatase inhibitors are a recommended option of adjuvant endocrine treatment for postmenopausal patients affected by early breast cancer, but are contraindicated in premenopausal women and in those with residual ovarian function. Women over 40 years of age with chemotherapy-induced amenorrhea and routine hormonal levels consistent with menopause may receive an aromatase inhibitor as adjuvant endocrine treatment. For these women, the tools available for identifying menopausal status do not appear to be completely reliable. Herewith, attention is focused on the pathophysiology of ovarian toxicity induced by cytotoxic agents and also on the potential of methods that may be useful in the diagnosis of chemotherapy-induced menopause in patients treated with adjuvant chemotherapy for early endocrine-responsive breast cancer. Moreover, practical approaches are proposed to distinguish truly menopausal women that would benefit from aromatase inhibitors from those with transient or persistent chemotherapy-induced amenorrhea. |
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Authors:
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Francesco Torino; Agnese Barnabei; Liana De Vecchis; Marialuisa Appetecchia; Lidia Strigari; Salvatore M Corsello |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
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Title: Endocrine-related cancer Volume: - ISSN: 1479-6821 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436481 Medline TA: Endocr Relat Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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F Torino, Department of Internal Medicine, Chair of Medical Oncology, University of Rome "Tor Vergata", Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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