| Recognition of viral single-stranded RNA by Toll-like receptors. | |
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MedLine Citation:
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PMID: 18241955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Toll-like receptors (TLR), mediating innate immune activation upon recognition of viral nucleic acids, represent promising targets for the development of adjuvants. Therefore, there is great interest in unraveling the underlying mechanisms of ligand recognition. Studies aiming to identify which sequences, nucleic acid modifications and molecular moieties of viral nucleic acids trigger or inhibit TLR activation have allowed insights into this subject, yet there are still many aspects of innate recognition of viral nucleic acids which are only partially understood. This review discusses our current understanding of TLR-mediated recognition of viral single-stranded RNA (ssRNA) by TLR7 and TLR8. Oligoribonucleotides (ORN) and small immune response modifiers such as imidazoquinolines with agonist function have served as tools to study ligand recognition. In addition, there is increasing evidence that TLR-mediated recognition of mammalian ssRNA triggers innate immune activation and plays a role in autoimmunity. Thus the development of suitable TLR7 and TLR8 antagonists could pave the way for therapeutic intervention of particular autoimmune diseases. |
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Authors:
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Sandra S Diebold |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-12-27 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 60 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 813-23 Citation Subset: IM |
Affiliation:
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King's College London, 2nd Floor Borough Wing, Peter Gorer Department of Immunobiology, Guy's Hospital, London SE1 9RT, United Kingdom. sandra.diebold@kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immunotherapy Ligands RNA, Viral / physiology* Toll-Like Receptor 7 / physiology Toll-Like Receptor 8 / physiology Toll-Like Receptors / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/RNA, Viral; 0/Toll-Like Receptor 7; 0/Toll-Like Receptor 8; 0/Toll-Like Receptors |
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