Document Detail


Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy: new cases and review of the main dysmorphological findings.
MedLine Citation:
PMID:  23448904     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Thalidomide is the best-known teratogen worldwide. It was first marketed as a sedative in the late 1950s, but the birth of ∼10 000 children with birth defects resulted in the withdrawal of thalidomide from the market in 1962. Thalidomide embryopathy affects almost all organs but the main defects are concentrated in the limbs, eyes, ears, and heart. Shortly after the withdrawal of thalidomide from the market, its effectiveness in the treatment of erythema nodosum leprosum, an inflammatory condition resulting from leprosy, was reported and since the mid-1990s, the drug has been used widely in the treatment of cancers and autoimmune diseases, among other conditions. 40 000 new cases of leprosy are diagnosed every year in Brazil. Although there is a strict legislation for the prescription and use of thalidomide in Brazil, cases of thalidomide embryopathy have continued to be reported. Here, we present two new cases of thalidomide embryopathy identified in 2011 and review the major clinical findings in the literature that can aid the identification of the embryopathy.
Authors:
Fernanda S L Vianna; Lavínia Schüler-Faccini; Julio César L Leite; Silvia H C de Sousa; Lea Márcia M da Costa; Murilo F Dias; Elaine F Morelo; Maria Juliana R Doriqui; Claudia M Maximino; Maria Teresa V Sanseverino
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Clinical dysmorphology     Volume:  22     ISSN:  1473-5717     ISO Abbreviation:  Clin. Dysmorphol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9207893     Medline TA:  Clin Dysmorphol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  59-63     Citation Subset:  -    
Affiliation:
aINAGEMP - National Institute of Population Medical Genetics bSIAT - Teratogen Information Service cMedical Genetics Service, Hospital de Clinicas2de Porto Alegre dGenetics Department, Universidade Federal do Rio Grande do Sul, Porto Alegre eMaternal and Child Hospital Complex of Maranhão, Maternity Dr Benedito Leite and Hospital Juvencio Mattos fDepartment of Health, State of Maranhão gMaternal and Child Health Post Graduation Program, Federal University of Maranhao, Sao Luis hNational Leprosy Program - PNH, Health Vigilance Secretariat - SVS, Ministry of Health iDepartment of Pharmacovigilance/National Sanitary Vigilance Agency - ANVISA, Brasilia DF jBrazilian Association of People with Thalidomide Syndrome - ABPST, Sao Paulo, Brazil.
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