Document Detail

Recognition of hemophilia A in an elderly patient.
MedLine Citation:
PMID:  9866274     Owner:  NLM     Status:  MEDLINE    
Hemophilia A (classic hemophilia) is an hereditary coagulation disorder characterized by the absence, severe deficiency, or defective functioning of plasma coagulation factor VIII. It is inherited in an X-linked recessive manner and occurs almost exclusively in males. The first manifestations of bleeding are usually first noted as a young child since most of the patients with hemophilia A have a profound deficiency of factor VIII (less than 1% of normal value). However, in mild hemophilia (5-25% of normal level of factor VIII) the condition may escape detection with many of the patients developing bleeding only after trauma or surgery. Hemophilia A is the result of a recent genetic mutation in approximately one third of patients, for whom often there is no family history of a bleeding disorder. Here we present an elderly male patient with spontaneous bleeding in an extremity that has coagulation studies consistent with the diagnosis of hemophilia A. Physicians must be aware that mild hemophilia can present in this unusual manner and should consider this possibility in patients that have unexplained bleeding even if there is no clear personal or family history of an hereditary coagulation disorder.
W Cáceres; S McCurdy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Boletín de la Asociación Médica de Puerto Rico     Volume:  90     ISSN:  0004-4849     ISO Abbreviation:  Bol Asoc Med P R     Publication Date:    1998 Apr-Jun
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505267     Medline TA:  Bol Asoc Med P R     Country:  PUERTO RICO    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Department of Hematology-Oncology, Veterans Administration Medical Center, San Juan, Puerto Rico 00927-5800.
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MeSH Terms
Heart Failure / complications
Hematoma / etiology
Hemophilia A / complications,  diagnosis*
Hypertension / complications
Middle Aged

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