| Recognition of fibrous dysplasia of bone mimicking skeletal metastasis on 18F-FDG PET/CT imaging. | |
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MedLine Citation:
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PMID: 20680622 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: Fibrous dysplasia of bone (FDB) reveals intense 18F-FDG uptake mimicking metastases on 18F-FDG PET/CT. We reviewed sites of FDB revealed by 18F-FDG PET/CT imaging to allow identification of this abnormality. MATERIALS AND METHODS: Eleven patients (7 male, 4 female, aged 16-78 years) were evaluated after 55 MBq (0.15 mCi)/kg 18F-FDG utilizing a 16-slice multiple detector CT (MDCT) whole-body PET scanner, with LOR algorithm 3D reconstruction. One- and 2-h imaging was performed in 9 patients. Standard uptake value (SUV) for each lesion, on early and delayed imaging, was calculated. Lesions were confirmed in 6 patients by biopsy. The PET images correlated with MDCT to establish the imaging characteristics. RESULTS: Solitary lesions were found in 4 patients, two lesions in 1 patient, and in 6 patients there were multiple bone lesions. The SUV(early) ranged from 1.23 to 9.64 with an average of 3.76 ± 2.40. The SUV(delayed) ranged from 1.76 to 11.42 with an average of 4.51 ± 3.07. The SUV(delayed) decreased or increased slightly (-31% to 5%) in 6 of our patients, and increased significantly (11% to 39%) in 3. There was a negative correlation between SUVs and age, as well as the number of affected bones. CONCLUSIONS: In our study, FDB had wide skeletal distribution with variability of 18F-FDG uptake and CT appearance. SUV in the delayed stage was seen to either decrease or increase on dual-time 18F-FDG PET scanning. It is very important to recognize the characteristics of this skeletal dysplasia to allow differentiation from skeletal metastasis. |
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Authors:
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Ming Gang Su; Rong Tian; Qiu Ping Fan; Ye Tian; Fang Lan Li; Lin Li; An Ren Kuang; John Howard Miller |
Publication Detail:
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Type: Journal Article Date: 2010-08-02 |
Journal Detail:
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Title: Skeletal radiology Volume: 40 ISSN: 1432-2161 ISO Abbreviation: Skeletal Radiol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701953 Medline TA: Skeletal Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 295-302 Citation Subset: IM |
Affiliation:
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National Key Discipline of Medical Imaging and Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University School of Medicine, 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, People's Republic of China, suminggang@sina.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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