Document Detail


Recognition of facial features of fetal alcohol syndrome in the newborn.
MedLine Citation:
PMID:  15095468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnosis of an infant, especially a newborn, with fetal alcohol spectrum disorder is difficult due to the fact that not all of the features are apparent at that time. Many cases are also missed due to inadequate knowledge of the mother's drinking pattern and because of the examining physician's lack of experience with the disorder. While conducting a study of the use of maternal blood markers to determine alcohol use in pregnancy, we have evaluated systematically the effects of alcohol on the newborn infant. We have developed a facial scoring system consisting of six of the features commonly seen in children with fetal alcohol syndrome (FAS) and present preliminary data about its use. By using a cutoff of four or more of these six features, there is a significant correlation with the presence of these features and the mother's self-reported alcohol use. In addition, there has been no significant difference in the frequency of positive scores between newborns of Caucasian or Black ancestry. We propose that this system may be useful in the assessment of newborn infants at high risk because of alcohol exposure during pregnancy.
Authors:
Joan Marilyn Stoler; Lewis Ball Holmes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of medical genetics. Part C, Seminars in medical genetics     Volume:  127C     ISSN:  1552-4868     ISO Abbreviation:  -     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-11-24     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235745     Medline TA:  Am J Med Genet C Semin Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Affiliation:
Genetics and Teratology Unit, Massachusetts General Hospital, 55 Fruit Street, Warren 901, Boston, MA 02114, USA. jstoler@partners.org
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / adverse effects
Birth Weight / drug effects
Facies*
Female
Fetal Alcohol Syndrome / diagnosis*
Humans
Infant, Newborn
Intelligence / drug effects
Pregnancy
Skull / drug effects,  growth & development

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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