Document Detail

Recognition, diagnosis, and treatment of mitochondrial myopathies in endurance athletes.
MedLine Citation:
PMID:  16144587     Owner:  NLM     Status:  MEDLINE    
Endurance athletes complaining of muscle pains concomitant with fatigue and exercise intolerance provide a diagnostic challenge. When the most common causes have been ruled out, the presence of metabolic myopathies, including mitochondrial myopathies (MMs), should be considered. MMs are a group of diseases characterized by inadequate mitochondrial ATP production needed for the energetic requirement of the exercising muscles. Athletes with myalgia, fatigue, dyspnea, and muscular cramping should be questioned for history of rhabdomyolysis or myoglobinuria as well as detailed family history, given the predominant matrilinear inheritance of MMs. In all suspected cases, blood lactate and ventilatory response on effort plus muscle biopsy for histologic and molecular studies are recommended. Therapeutic recommendations consist of a set of instructions including genetic counseling, awareness of possible myoglobinuric episodes, and controlled exercise training.
Massimo Testa; Franco M Navazio; Jennifer Neugebauer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current sports medicine reports     Volume:  4     ISSN:  1537-8918     ISO Abbreviation:  Curr Sports Med Rep     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-07     Completed Date:  2006-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134380     Medline TA:  Curr Sports Med Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-7     Citation Subset:  IM    
Sports Performance Program, University of California, Davis Medical Center, Sacramento, CA 95816, USA.
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MeSH Terms
Exercise Tolerance
Mitochondrial Myopathies / diagnosis*,  therapy
Physical Endurance*
Sports Medicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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