| Recognition, diagnosis, and treatment of mitochondrial myopathies in endurance athletes. | |
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MedLine Citation:
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PMID: 16144587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endurance athletes complaining of muscle pains concomitant with fatigue and exercise intolerance provide a diagnostic challenge. When the most common causes have been ruled out, the presence of metabolic myopathies, including mitochondrial myopathies (MMs), should be considered. MMs are a group of diseases characterized by inadequate mitochondrial ATP production needed for the energetic requirement of the exercising muscles. Athletes with myalgia, fatigue, dyspnea, and muscular cramping should be questioned for history of rhabdomyolysis or myoglobinuria as well as detailed family history, given the predominant matrilinear inheritance of MMs. In all suspected cases, blood lactate and ventilatory response on effort plus muscle biopsy for histologic and molecular studies are recommended. Therapeutic recommendations consist of a set of instructions including genetic counseling, awareness of possible myoglobinuric episodes, and controlled exercise training. |
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Authors:
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Massimo Testa; Franco M Navazio; Jennifer Neugebauer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current sports medicine reports Volume: 4 ISSN: 1537-8918 ISO Abbreviation: Curr Sports Med Rep Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-07 Completed Date: 2006-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134380 Medline TA: Curr Sports Med Rep Country: United States |
Other Details:
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Languages: eng Pagination: 282-7 Citation Subset: IM |
Affiliation:
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Sports Performance Program, University of California, Davis Medical Center, Sacramento, CA 95816, USA. massimo.testa@ucdmc.ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Exercise Tolerance Humans Mitochondrial Myopathies / diagnosis*, therapy Physical Endurance* Sports Medicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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