| Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy. | |
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MedLine Citation:
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PMID: 19473893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The EPKi system (Pentax, Japan) enables resolution above HDTV. Aim of the study was to test the efficacy of HD+ alone and with the new post-processing digital filter i-Scan or chromoendoscopy (Methylene blue 0.1%) in screening for colorectal cancer. We focused on lesions less than 5 mm as a surrogate marker for the optical possibilities of the EPKi system. METHODS: The last 30 cm of the colon in a screening population were inspected with HD+ alone, in combination with i-Scan (2:1 randomisation) and subsequently with chromoendoscopy. All lesions were characterized and targeted biopsies were performed. RESULTS: i-Scan augmented in 69 patients the identification of lesions from 176 to 335 (p<0.001) and chromoendoscopy to 646 (p<0.001). The additional lesions were mainly flat (type IIb, 74%), which were only recognized using i-Scan or chromoendoscopy. The amount of neoplasias was not significantly different (HD+: 5, i-Scan: 11, Chromoendoscopy: 11), but all could correctly be predicted using i-Scan or chromoendoscopy. CONCLUSIONS: HD+ colonoscopy with and without i-Scan unmask a plethora of small lesions but chromoendoscopy can even advance the number. However, i-Scan was able to predict neoplasia as precisely as chromoendoscopy and might shortly replace chromoendoscopy as a more time efficient tool. |
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Authors:
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A Hoffman; C Kagel; M Goetz; A Tresch; J Mudter; S Biesterfeld; P R Galle; M F Neurath; R Kiesslich |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-05-26 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 42 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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I. Med. Clinic, Johannes Gutenberg University Mainz, Germany. AHoff66286@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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pathology* Colonic Polyps / pathology* Colonoscopy / methods* Colorectal Neoplasms / pathology* Female Humans Hyperplasia / pathology Image Interpretation, Computer-Assisted / instrumentation, methods* Male Methylene Blue / diagnostic use Middle Aged |
| Chemical | |
Reg. No./Substance:
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61-73-4/Methylene Blue |
| Comments/Corrections | |
Comment In:
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Dig Liver Dis. 2010 Jan;42(1):18-9
[PMID:
19955024
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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