| Recognition of T.A interruption by 2',4'-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation. | |
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MedLine Citation:
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PMID: 18255299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T.A interruption. |
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Authors:
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Satoshi Obika; Hiroyasu Inohara; Yoshiyuki Hari; Takeshi Imanishi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-25 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 16 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-06-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 2945-54 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Pairing* Benzamides / chemistry* Bridged Compounds Nucleic Acid Conformation Nucleic Acid Denaturation Nucleic Acid Hybridization Nucleic Acids / chemistry* Oligonucleotides / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Bridged Compounds; 0/Nucleic Acids; 0/Oligonucleotides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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