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Recognition of Streptococcus pneumoniae and MDP by NOD2 results in a potent induction of MMP-9, which can be controlled by LPS stimulation.
MedLine Citation:
PMID:  25183734     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Matrix metallopeptidase-9 (MMP-9) is a protease involved in the degradation of extracellular matrix collagen. Evidence suggests that MMP-9 is involved in the pathogenesis during a Streptococcus pneumoniae infection. However, not much is known about the induction of MMP-9 and the regulatory processes involved. We show that the Gram-positive bacteria used in this study induce high amounts of MMP-9 in contrast to the Gram-negative bacteria that were used. An important PAMP for Gram-positive bacteria is muramyl dipeptide (MDP). MDP is a very potent inducer of MMP-9 and showed a dose-dependent MMP-9 induction. Experiments using PBMCs from Crohn's disease patients with a non-functional NOD2 show that MMP-9 induction by Streptococcus pneumoniae and MDP is NOD2 dependent. Increasing amounts of LPS, an important PAMP for Gram-negative bacteria, resulted in decreasing amounts of MMP-9. Moreover, the induction of MMP-9 by MDP could be counteracted by simultaneously adding LPS. The inhibition of MMP-9 expression by LPS was found to be post-transcriptional regulated, independent of metalloproteinase-1 (TIMP-1), an endogenous inhibitor of MMP-9. Collectively, these data show that Streptococcus pneumoniae is able to induce high amounts of MMP-9. These high MMP-9 levels could potentially be involved in Streptococcus pneumoniae pathogenesis.
Authors:
Marloes Vissers; Yvonne Hartman; Laszlo Groh; Dirk J de Jong; Marien I de Jonge; Gerben Ferwerda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-2
Journal Detail:
Title:  Infection and immunity     Volume:  -     ISSN:  1098-5522     ISO Abbreviation:  Infect. Immun.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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