Document Detail


Recognition of Early Myocardial Infarction by Immunohistochemical Staining with Cardiac Troponin-I and Complement C9*
MedLine Citation:
PMID:  22583124     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  The diagnosis of early myocardial infarction (MI) after death, especially in the first few hours (c. 6 h) after the onset of MI, poses a challenge to the forensic pathologists. During this time, the damaged myocardium does not show grossly identifiable morphological changes and may not be recognized even with routine histological microscopic examination. However, the infarcted cardiac tissue releases certain chemicals that can be detected microscopically, two of these being cardiac troponin-I (CT-I) and complement C9 (C9). This study utilizes the importance of these two biomarkers immunohistochemically in an attempt to identify this early phase of MI. This study reveals that the early phase of MI of <6 h duration may be detected through immunohistochemical staining with CT-I and C9. The ischemic/infarcted cardiac myofibers in the <6 h group display reduced/absent CT-I staining as well as positive C9 staining.
Authors:
Shashi Kiran Jasra; Cherryl Badian; Iain Macri; Paul Ra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-14
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Academy of Forensic Sciences.
Affiliation:
Center for Inter-Faculty Programs: Forensics, University of Windsor, Windsor, 401 Sunset Ave., ON N9B3P4, Canada. Department of Pathology, Windsor Regional Hospital, 401 Sunset Ave., Windsor, ON N8W1L9, Canada.
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