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Recognition of Coxiella burnetii by Toll-like receptors and NOD-like receptors Recognition of C. burnetii by TLRs and NLRs.
MedLine Citation:
PMID:  25246533     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:  Infection with Coxiella burnetii can lead to acute and chronic Q fever. Toll-like receptors (TLR)1, TLR2, TLR4, TLR6, NOD1, NOD2 and the MAP-kinases are central in the innate immune response against micro-organisms, but little is known about their role in the recognition of C. burnetii in humans.
METHODS:  Human peripheral blood mononuclear cells were stimulated with C. burnetii Nine Mile and the Dutch outbreak isolate C. burnetii 3262. TLRs were inhibited using specific antibodies or antagonists. Additionally, the influence of human polymorphisms in TLRs and NLRs on C. burnetii-induced cytokine production was assessed.
RESULTS:  Inhibition of TLR2, p38, JNK and ERK led to decreased cytokine responses in C. burnetii-stimulated human PBMCs. Humans with polymorphisms in TLR1 and NOD2 had reduced cytokine production compared to humans with wild-type genotypes after stimulation. Interestingly, polymorphisms in TLR6 led to decreased cytokine production after C. burnetii 3262, but not after C. burnetii NM stimulation.
CONCLUSION:  The TLR1/TLR2 heterodimer and NOD2 are important recognition receptors for the induction of cytokine responses against C. burnetii in humans. Furthermore, an interesting finding was the divergent recognition of C. burnetii NM and C. burnetii 3262.
Authors:
Anne Ammerdorffer; Teske Schoffelen; Mark S Gresnigt; Marije Oosting; Martijn H den Brok; Shahla Abdollahi-Roodsaz; Thirumala-Devi Kanneganti; Dirk J de Jong; Marcel van Deuren; Hendrik-Jan Roest; Johanna M Rebel; Mihai G Netea; Leo A B Joosten; Tom Sprong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-22
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-23     Completed Date:  -     Revised Date:  2014-9-24    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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