Document Detail


Recognition of CD1d-restricted antigens by natural killer T cells.
MedLine Citation:
PMID:  23154222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines following T cell receptor (TCR) activation and can shape the immune response in many different settings. There are two main NKT cell subsets: type I NKT cells are typically characterized by the expression of a semi-invariant TCR, whereas the TCRs expressed by type II NKT cells are more diverse. This Review focuses on the defining features and emerging generalities regarding how NKT cells specifically recognize self, microbial and synthetic lipid-based antigens that are presented by CD1d. Such information is vitally important to better understand, and fully harness, the therapeutic potential of NKT cells.
Authors:
Jamie Rossjohn; Daniel G Pellicci; Onisha Patel; Laurent Gapin; Dale I Godfrey
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-16
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  12     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-02-08     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  845-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Bacterial / immunology
Antigens, CD1d / immunology*
Autoantigens / immunology
Autoimmunity
Humans
Mice
Natural Killer T-Cells / immunology*
Thymus Gland / immunology
Vaccines, Synthetic / immunology
Grant Support
ID/Acronym/Agency:
AI090450/AI/NIAID NIH HHS; AI092108/AI/NIAID NIH HHS; R01 AI092108/AI/NIAID NIH HHS; R21 AI090450/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, CD1d; 0/Autoantigens; 0/Vaccines, Synthetic
Comments/Corrections

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