| Recognising the Sertoli-cell-only (SCO) syndrome: a case study. | |
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MedLine Citation:
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PMID: 21219389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Total Sertoli-cell-only (SCO) syndrome is often confused with a focal SCO picture, in which testicular illness caused damage to seminiferous tubules and compromised the Sertoli cell range of maturation and functions, but from which still some spermatozoa can be retrieved for assisted reproductive techniques. Here, a possibly new SCO syndrome phenotype is reported exhibiting complete lack of germ cells despite normal architecture of the seminiferous tubules with presence of mature Sertoli cells and normal Leydig cells in the intertubular tissue. Sertoli cells are immunonegative for the prepubertal differentiation markers cytokeratin-18, anti-Muellerian hormone and M2A antigen, but reveal a positive signal for the gap junctional protein connexin 43 known to be expressed in Sertoli cells with an adult type of differentiation. The complete lack of germ cells in combination with fully differentiated adult-type Sertoli cells in this case is in contradiction with known SCO subtypes and with the current hypothesis of reciprocal regulation of Sertoli and germ cell differentiation. |
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Authors:
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R Anniballo; R Brehm; K Steger |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Andrologia Volume: 43 ISSN: 1439-0272 ISO Abbreviation: Andrologia Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: 2011-04-28 Revised Date: 2011-12-20 |
Medline Journal Info:
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Nlm Unique ID: 0423506 Medline TA: Andrologia Country: Germany |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Verlag GmbH. |
Affiliation:
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John MacLeod Andrology & Male Infertility Center, Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Mullerian Hormone / metabolism Biopsy Cell Differentiation Connexin 43 / metabolism Humans Keratin-18 / metabolism Leydig Cells / pathology Male Phenotype* Sertoli Cell-Only Syndrome / diagnosis*, metabolism, pathology* Sertoli Cells / metabolism, pathology* Testis / pathology |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Keratin-18; 80497-65-0/Anti-Mullerian Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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