| Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation. | |
| | |
MedLine Citation:
|
PMID: 17367339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Optimization of antibody affinity is a hallmark of the humoral immune response. It takes place in hundreds of transient microstructures called germinal centers (GCs). Their function and time-dependent behavior are subjects of active investigation. According to a generally accepted notion, their individual kinetics follows the average kinetics of all GCs present in the observed lymphatic tissue. In this review, we challenge this view and point out, with the help of mathematical simulations, that inferring the kinetics of individual GCs from cross-sectional evaluation of GC kinetics is virtually impossible. Thus, the time course of individual GCs is open to conjecture. For instance, one possible interpretation is that GCs exist for a time span considerably shorter than that of the observed average kinetics. We explore the implications of different temporal organizations of GCs in the light of the hypothesis that GC B-cell emigrants recolonize GC niches. This assumption leads to a view where GCs work in parallel but are linked by recirculation of B-cell emigrants. In this view, interleaved global and local competition provide for an implementation of multiple levels of B-cell selection in affinity maturation. The concepts of iteration, all-or-none behavior, and phasic mutation schedule are discussed in the light of this hypothesis. |
| | |
Authors:
|
Michal Or-Guil; Nicole Wittenbrink; Armin A Weiser; Johannes Schuchhardt |
Related Documents
:
|
21347379 - Selective processing of multiple features in the human brain: effects of feature type a... 11823229 - Biotransformation and bioconcentration of steroid estrogens by chlorella vulgaris. 6197369 - Identification of the mt3 molecule using two-dimensional gel electrophoresis and alloan... 16208369 - Pterosaur diversity and faunal turnover in cretaceous terrestrial ecosystems in china. 12577909 - Kaya kalpa methods adopted by siddars: a scientific approach. 7264969 - Mechanical properties and myosin light chain composition of skinned muscle fibres from ... 19015199 - Adaptation of reactive and voluntary saccades: different patterns of adaptation reveale... 19163259 - Frequency interpretation of tidal peak in intracranial pressure wave. 17754549 - Role of shallow phase changes in the subduction of oceanic crust. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Immunological reviews Volume: 216 ISSN: 0105-2896 ISO Abbreviation: Immunol. Rev. Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-19 Completed Date: 2007-05-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
|
Languages: eng Pagination: 130-41 Citation Subset: IM |
Affiliation:
|
Systems Immunology Group, Institute for Theoretical Biology, Humboldt University, Berlin, Germany. m.orguil@biologie.hu-berlin.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies / immunology* B-Lymphocytes / immunology* Cell Movement* Germinal Center / cytology, immunology* Humans Kinetics Models, Immunological* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modeling T- and B-cell growth and differentiation.
Next Document: Idiotypic networks: toward a renaissance?