Document Detail

Reciprocal relationships between general (Propofol) anesthesia and circadian time in rats.
MedLine Citation:
PMID:  16641940     Owner:  NLM     Status:  MEDLINE    
Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (+/-2 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant resetting effect at other times of the day. Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock.
Etienne Challet; Sylviane Gourmelen; Paul Pevet; Philippe Oberling; Laure Pain
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-12
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  32     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-04-05     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-35     Citation Subset:  IM    
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, CNRS (UMR7168), University L. Pasteur, Strasbourg, France.
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MeSH Terms
Analysis of Variance
Anesthetics, Intravenous / pharmacology*
Behavior, Animal / drug effects*
Body Temperature / drug effects
Circadian Rhythm / drug effects*,  physiology
Motor Activity / drug effects
Propofol / pharmacology*
Rats, Long-Evans
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

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