Document Detail

Reciprocal modulation of sweet taste by leptin and endocannabinoids.
MedLine Citation:
PMID:  20865375     Owner:  NLM     Status:  In-Process    
Sweet taste perception is important for animals to detect carbohydrate source of calories and has a critical role in the nutritional status of animals. Recent studies demonstrated that sweet taste responses can be modulated by leptin and endocannabinoids [anandamide (N-arachidonoylethanolamine) and 2-arachidonoyl glycerol]. Leptin is an anorexigenic mediator that reduces food intake by acting on hypothalamic receptor, Ob-Rb. Leptin is shown to selectively suppress sweet taste responses in wild-type mice but not in leptin receptor-deficient db/db mice. In marked contrast, endocannabinoids are orexigenic mediators that act via CB(1) receptors in hypothalamus and limbic forebrain to induce appetite and stimulate food intake. In the peripheral taste system, endocannabinoids also oppose the action of leptin and enhance sweet taste sensitivities in wild-type mice but not in mice genetically lacking CB(1) receptors. These findings indicate that leptin and endocannabinoids not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors.
Mayu Niki; Masafumi Jyotaki; Ryusuke Yoshida; Yuzo Ninomiya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  52     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  101-14     Citation Subset:  IM    
Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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