Document Detail

Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition.
MedLine Citation:
PMID:  15042019     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to test the hypothesis that peroxisome proliferator activated receptor-gamma (PPAR-gamma) is expressed in intrauterine tissues before active term human parturition, and that its repression is associated with up-regulation of cyclooxygenase-2 (COX-2). STUDY DESIGN: Specimens were collected from women with term singleton pregnancies after spontaneous labor or cesarean section before labor, prepared for immunoblot and immunohistochemical analysis, and probed for PPAR-gamma or COX-2. RESULTS: PPAR-gamma expression was prominent in fetal membranes and placenta before active labor. After labor, PPAR-gamma expression was significantly reduced in fetal membranes, but not in placenta. The ratio of COX-2:PPAR-gamma was significantly elevated in fetal membranes with labor. PPAR-gamma immunostaining was prominent in syncytiotrophoblast, extravillous cytotrophoblasts, and cells of the amnion and chorion. COX-2 immunostaining was abundant in the amnion and rare in the placenta. CONCLUSION: PPAR-gamma is highly expressed in term intrauterine tissues. In fetal membranes, PPAR-gamma levels are reduced once active labor commences, coincidental with a relative increase in COX-2 expression.
Lisa R Dunn-Albanese; William E Ackerman; Yubing Xie; Jay D Iams; Douglas A Kniss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  190     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-16     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal-Fetal Medicine, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio, USA.
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MeSH Terms
Cyclooxygenase 2
Extraembryonic Membranes / metabolism
Gestational Age
Isoenzymes / metabolism*
Labor, Obstetric / physiology*
Membrane Proteins
Parturition / metabolism*
Prostaglandin-Endoperoxide Synthases / metabolism*
Receptors, Cytoplasmic and Nuclear / metabolism*
Tissue Distribution
Transcription Factors / metabolism*
Uterus / metabolism*
Grant Support
Reg. No./Substance:
0/Isoenzymes; 0/Membrane Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; EC 2; EC protein, human; EC Synthases

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