Document Detail


Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition.
MedLine Citation:
PMID:  15042019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to test the hypothesis that peroxisome proliferator activated receptor-gamma (PPAR-gamma) is expressed in intrauterine tissues before active term human parturition, and that its repression is associated with up-regulation of cyclooxygenase-2 (COX-2). STUDY DESIGN: Specimens were collected from women with term singleton pregnancies after spontaneous labor or cesarean section before labor, prepared for immunoblot and immunohistochemical analysis, and probed for PPAR-gamma or COX-2. RESULTS: PPAR-gamma expression was prominent in fetal membranes and placenta before active labor. After labor, PPAR-gamma expression was significantly reduced in fetal membranes, but not in placenta. The ratio of COX-2:PPAR-gamma was significantly elevated in fetal membranes with labor. PPAR-gamma immunostaining was prominent in syncytiotrophoblast, extravillous cytotrophoblasts, and cells of the amnion and chorion. COX-2 immunostaining was abundant in the amnion and rare in the placenta. CONCLUSION: PPAR-gamma is highly expressed in term intrauterine tissues. In fetal membranes, PPAR-gamma levels are reduced once active labor commences, coincidental with a relative increase in COX-2 expression.
Authors:
Lisa R Dunn-Albanese; William E Ackerman; Yubing Xie; Jay D Iams; Douglas A Kniss
Related Documents :
1388439 - Treatment and outcomes of psychotic patients during pregnancy and childbirth.
22773699 - Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glu...
17368909 - Digital rotation from occipito-posterior to occipito-anterior decreases the need for ce...
7381299 - Levels of free fatty acids and arachidonic acid in pregnancy and labor.
8378009 - Pregnancy after mustard repair for transposition of the great arteries.
6898709 - The second time around: parity and birth experience.
16631099 - Cessation of asthma medication in early pregnancy.
9201819 - Vitamin a and its congeners.
11356809 - Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fet...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  190     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-16     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal-Fetal Medicine, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cyclooxygenase 2
Extraembryonic Membranes / metabolism
Female
Gestational Age
Humans
Immunoblotting
Immunohistochemistry
Isoenzymes / metabolism*
Labor, Obstetric / physiology*
Membrane Proteins
Parturition / metabolism*
Pregnancy
Prostaglandin-Endoperoxide Synthases / metabolism*
Receptors, Cytoplasmic and Nuclear / metabolism*
Tissue Distribution
Transcription Factors / metabolism*
Uterus / metabolism*
Grant Support
ID/Acronym/Agency:
HD35881/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Membrane Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elective cesarean delivery plus short-course lamivudine and zidovudine for the prevention of mother-...
Next Document:  Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase exp...