| Reciprocal expression of peroxisome proliferator-activated receptor-gamma and cyclooxygenase-2 in human term parturition. | |
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MedLine Citation:
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PMID: 15042019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to test the hypothesis that peroxisome proliferator activated receptor-gamma (PPAR-gamma) is expressed in intrauterine tissues before active term human parturition, and that its repression is associated with up-regulation of cyclooxygenase-2 (COX-2). STUDY DESIGN: Specimens were collected from women with term singleton pregnancies after spontaneous labor or cesarean section before labor, prepared for immunoblot and immunohistochemical analysis, and probed for PPAR-gamma or COX-2. RESULTS: PPAR-gamma expression was prominent in fetal membranes and placenta before active labor. After labor, PPAR-gamma expression was significantly reduced in fetal membranes, but not in placenta. The ratio of COX-2:PPAR-gamma was significantly elevated in fetal membranes with labor. PPAR-gamma immunostaining was prominent in syncytiotrophoblast, extravillous cytotrophoblasts, and cells of the amnion and chorion. COX-2 immunostaining was abundant in the amnion and rare in the placenta. CONCLUSION: PPAR-gamma is highly expressed in term intrauterine tissues. In fetal membranes, PPAR-gamma levels are reduced once active labor commences, coincidental with a relative increase in COX-2 expression. |
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Authors:
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Lisa R Dunn-Albanese; William E Ackerman; Yubing Xie; Jay D Iams; Douglas A Kniss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 190 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2004-04-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 809-16 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Laboratory of Perinatal Research and Division of Maternal-Fetal Medicine, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cyclooxygenase 2 Extraembryonic Membranes / metabolism Female Gestational Age Humans Immunoblotting Immunohistochemistry Isoenzymes / metabolism* Labor, Obstetric / physiology* Membrane Proteins Parturition / metabolism* Pregnancy Prostaglandin-Endoperoxide Synthases / metabolism* Receptors, Cytoplasmic and Nuclear / metabolism* Tissue Distribution Transcription Factors / metabolism* Uterus / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD35881/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Membrane Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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