Document Detail

Reciprocal embryo transfer between SHR and WKY. II. Effect on cardiovascular development.
MedLine Citation:
PMID:  1773527     Owner:  NLM     Status:  MEDLINE    
In order to study the in vivo effect of putative hypertensinogenic factors on early development of the cardiovascular system, embryos were reciprocally transferred between WKY and SHR to allow embryonic and fetal development of WKY in a hypertensive intrauterine environment and SHR in a non-hypertensive uterine environment. In one day-old neonates blood vessel dimensions and blood pressures were assessed. Pressures were also measured in animals which matured to the adult stage to determine whether there were any long-term effects on pressure of having developed in an in utero environment different from the one they would have naturally experienced. The data indicate that there are no consistent effects of intrauterine environment on vascular development, as indicated by the fact that normalized wall/lumen ratios were not different between normal and transferred animals, and immediate and long-term pressures were also similar in normal and transferred groups.
S D Gray
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  13     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-02     Completed Date:  1992-03-02     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  963-9     Citation Subset:  IM    
Department of Human Physiology, School of Medicine, University of California, Davis 95616.
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MeSH Terms
Cardiovascular System / embryology*
Embryo Transfer / methods*
Embryonic and Fetal Development / physiology
Maternal-Fetal Exchange / physiology*
Rats, Inbred SHR
Rats, Inbred WKY
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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