Document Detail

Reciprocal effects of prolactin and thyroxine on the growth rate of rat pups from weaning to puberty.
MedLine Citation:
PMID:  756883     Owner:  NLM     Status:  MEDLINE    
Prolactin and thyroxine were added to the daily diet of rat pups from weaning to puberty (days 20--40). While prolactin significantly retarted the pups' growth, thyroxine stimulated growth and even compensated for the depression caused by prolactin. The significant retardation in the growth of the prolactin-treated pups around days 30--35 of age indicates that at that period they are extremely prolactin-dependent, thus confirming previous reports that exogenous prolactin inhibits its own endogenous secretion. On the other hand, the possible growth promotion caused by thyroxine is mild and does not initiate a feedback mechanism. This suggests that prolactin is indispensable for the normal development of the weaned, immature rat.
J Shani; G Goldhaber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  1     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  363-4     Citation Subset:  IM    
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MeSH Terms
Drug Combinations
Growth / drug effects*
Prolactin / pharmacology*
Sexual Maturation
Thyroxine / pharmacology*
Reg. No./Substance:
0/Drug Combinations; 7488-70-2/Thyroxine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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