Document Detail

Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants.
MedLine Citation:
PMID:  9988446     Owner:  NLM     Status:  MEDLINE    
By adulthood there is almost universal immunological memory to aeroallergens, and the presence of allergic disease appears to be related to the nature of the underlying T-helper (Th) cell cytokine responses. The hypothesis of this study is that adult patterns of allergen specific Th-cell memory (Th-2 polarized in atopics vs. Th1 in non-atopics) can be determined in early infancy. Mononuclear cell cytokine responses to house-dust mite were measured at 6-monthly intervals from birth to 2 years of age, using ELISA (IL-10, IL-13, IFN-gamma) and sqRT/PCR (IL-4, IL-5, IL-9, IFN-gamma) in normal infants (n = 14) with no family history or allergic symptoms, and infants with a family history and definite atopy by 2 years (n = 16). Both normals and atopics showed low-level Th2 skewed allergen-specific responses at birth with little accompanying IFN-gamma. The Th2 responses to house-dust mite were higher in normal newborns, who then show a rapid downregulation of these responses in the first year of life. Atopic infants instead show a consolidation of their neonatal patterns of Th2 polarized allergen specific immunity. Earlier studies indicate that neonates at high risk of atopy display diminished capacity for production of the Th1 cytokine IFN-gamma. The present study suggests for the first time that neonates who subsequently develop atopy also initially have reduced capacity to mount Th2 responses. However, in contrast to non-atopics who selectively downregulate their fetal Th2 polarized allergen-specific responses, atopic children display age-associated upregulation of Th2 immunity.
S L Prescott; C Macaubas; T Smallacombe; B J Holt; P D Sly; R Loh; P G Holt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  28 Suppl 5     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-04-23     Completed Date:  1999-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-44; discussion 50-1     Citation Subset:  IM; X    
TVW Telethon Institute for Child Health Research, West Perth, Western Australia, Australia.
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MeSH Terms
Allergens / immunology*
Child, Preschool
Cytokines / biosynthesis
Enzyme-Linked Immunosorbent Assay
Hypersensitivity, Immediate / immunology*
Immunologic Memory
Infant, Newborn
Lymphocyte Activation
Mites / immunology*
Ovalbumin / immunology
RNA, Messenger / metabolism
T-Lymphocytes / immunology*
Tetanus Toxoid / immunology
Th1 Cells / immunology,  metabolism
Th2 Cells / immunology,  metabolism
Reg. No./Substance:
0/Allergens; 0/Cytokines; 0/Dust; 0/RNA, Messenger; 0/Tetanus Toxoid; 9006-59-1/Ovalbumin

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