Document Detail

Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis.
MedLine Citation:
PMID:  20661924     Owner:  NLM     Status:  MEDLINE    
Human mesenchymal stem cells (hMSCs) are being considered for clinical trials of multiple sclerosis (MS). We examined the effects of adult bone marrow-derived hMSCs on responses of primary human Th1, Th17, and Th1/17 double-expressing T-cell subsets, all implicated in MS. As expected, soluble products from hMSCs inhibited Th1 responses; however, Th17 responses were increased. Secretion of interleukin (IL)-10, considered anti-inflammatory, was decreased. Pretreating hMSCs with the proinflammatory cytokine IL-1β accentuated these effects, and caused decreases in the Th1/17 subset. These findings underscore the importance of further preclinical work and immune-monitoring to define hMSC effects on disease-relevant immune responses under variable conditions.
Peter J Darlington; Marie-Noëlle Boivin; Christel Renoux; Moïra François; Jacques Galipeau; Mark S Freedman; Harold L Atkins; Jeffrey A Cohen; Luis Solchaga; Amit Bar-Or
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  68     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-5     Citation Subset:  IM    
Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada.
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MeSH Terms
Antigens, CD / metabolism
CD4-Positive T-Lymphocytes / classification,  drug effects,  immunology*
Cell Proliferation / drug effects
Cells, Cultured
Culture Media, Conditioned / pharmacology
Cytokines / immunology,  pharmacology
Enzyme-Linked Immunosorbent Assay / methods
Flow Cytometry / methods
Leukocytes, Mononuclear / drug effects,  immunology
Lymphocyte Activation / immunology
Mesenchymal Stem Cells / chemistry,  immunology*
T-Lymphocytes, Helper-Inducer / classification,  drug effects,  immunology
Th1 Cells / cytology*,  immunology
Grant Support
P30 CA43703/CA/NCI NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/Antigens, CD; 0/Culture Media, Conditioned; 0/Cytokines

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