| Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis. | |
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MedLine Citation:
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PMID: 20661924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human mesenchymal stem cells (hMSCs) are being considered for clinical trials of multiple sclerosis (MS). We examined the effects of adult bone marrow-derived hMSCs on responses of primary human Th1, Th17, and Th1/17 double-expressing T-cell subsets, all implicated in MS. As expected, soluble products from hMSCs inhibited Th1 responses; however, Th17 responses were increased. Secretion of interleukin (IL)-10, considered anti-inflammatory, was decreased. Pretreating hMSCs with the proinflammatory cytokine IL-1β accentuated these effects, and caused decreases in the Th1/17 subset. These findings underscore the importance of further preclinical work and immune-monitoring to define hMSC effects on disease-relevant immune responses under variable conditions. |
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Authors:
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Peter J Darlington; Marie-Noëlle Boivin; Christel Renoux; Moïra François; Jacques Galipeau; Mark S Freedman; Harold L Atkins; Jeffrey A Cohen; Luis Solchaga; Amit Bar-Or |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 68 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 540-5 Citation Subset: IM |
Affiliation:
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Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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metabolism CD4-Positive T-Lymphocytes / classification, drug effects, immunology* Cell Proliferation / drug effects Cells, Cultured Culture Media, Conditioned / pharmacology Cytokines / immunology, pharmacology Enzyme-Linked Immunosorbent Assay / methods Flow Cytometry / methods Humans Leukocytes, Mononuclear / drug effects, immunology Lymphocyte Activation / immunology Mesenchymal Stem Cells / chemistry, immunology* T-Lymphocytes, Helper-Inducer / classification, drug effects, immunology Th1 Cells / cytology*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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P30 CA43703/CA/NCI NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Culture Media, Conditioned; 0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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